Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus

Ryoichi Takayanagi, Toyoshi Inoguchi, Keizo Ohnaka

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

The involvement of reactive oxygen species in various diseases has been demonstrated almost in vitro or in animal studies and clinical studies supporting the involvement of reactive oxygen species are very few. Bilirubin has been recognized as an important antioxidant and also shown to have an inhibitory effect on the activity of NADPH oxidase, which may be an important source for superoxide production in various tissues. When the prevalence of vascular complcations was compared in diabetic patients with and without a congenital hyperbilirubinemia (Gilbert syndrome), the prevalence of retinopathy, macroalbuminuria and coronary artery disease in patients with Gilbert syndrome was about 20% of that in those without Gilbert syndrome. For study of lifestyle-related diseases, the Fukuoka Cohort was constructed from 2003 to 2009 in Kyushu area in Japan, which contains a total of 12,949 persons. Cross-sectional study of the Fukuoka Cohort revealed an inverse relation between serum bilirubin level and the prevalence of type 2 diabetes mellitus. A precursor of bilirubin, biliverdin-treated db/db mice exhibited less albuminuria and nephropathic changes. These effects were paralleled with normalization of oxidative stress markers and expression of NAD(P)H oxidase subunits in kidney. These results suggested that oxidative stress is an exacerbating factor of type 2 diabetes mellitus and that antioxidant therapies are of value to diabetic nephropathy.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

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Gilbert Disease
Oxidative stress
Medical problems
Bilirubin
Diabetes Mellitus
Oxidative Stress
NADPH Oxidase
Type 2 Diabetes Mellitus
Reactive Oxygen Species
Antioxidants
Biliverdine
Albuminuria
Hyperbilirubinemia
Diabetic Nephropathies
Superoxides
Blood Vessels
Life Style
Coronary Artery Disease
Japan
Animals

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus. / Takayanagi, Ryoichi; Inoguchi, Toyoshi; Ohnaka, Keizo.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 48, No. 1, 01.01.2011, p. 72-77.

Research output: Contribution to journalReview article

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