Clinical and immunological assessment of periodontal disease in japanese leprosy patients

Hideki Ohyama, Hiroshi Hongyo, Naoko Shimizu, Yoshikazu Shimizu, Fusanori Nishimura, Masatsugu Nakagawa, Hideo Arai, Nahoko Kato-Kogoe, Nobuyuki Terada, Atsushi Nagai, Shogo Takashiba, Hidemi Kurihara, Yoshio Nomura, Yoji Murayama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Periodontitis is a chronic inflammatory disease caused by the infection of periodontopathic bacteria in dental plaque. However, an individual's susceptibility to this disease appears to be associated with multiple genetic factors, as seen in the case of leprosy. In order to gain a better understanding of the pathophysiology of periodontal disease in subjects with leprosy, we investigated the clinical features of periodontitis and the immunological responses against periodontopathic bacteria in 382 subjects with a history of leprosy and 451 age-matched control subjects. The prevalence of periodontitis and the degree of periodontal pocket depth were found to be significantly higher in leprosy patients than in age-matched controls. Furthermore, a comparison of the clinical parameters of lepromatous leprosy (L-lep) and tuberculoid leprosy (T-lep) patients showed that the probing pocket depth of L-lep patients with periodontal disease was significantly higher than that for T-lep patients. In contrast, serum IgG titers against Porphyromonas gingivalis in L-lep patients were significantly lower than in T-lep patients. These results imply that L-lep patients show more severe periodontal disease than T-lep patients or agematched control subjects, and that low humoral immunity against P. gingivalis might be one of the genetic factors determining periodontal disease susceptibility in leprosy patients.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalJapanese Journal of Infectious Diseases
Volume63
Issue number6
Publication statusPublished - Dec 6 2010
Externally publishedYes

Fingerprint

Periodontal Diseases
Leprosy
Tuberculoid Leprosy
Lepromatous Leprosy
Periodontitis
Porphyromonas gingivalis
Disease Susceptibility
Periodontal Pocket
Bacteria
Dental Plaque
Humoral Immunity
Chronic Disease
Immunoglobulin G
Infection
Serum

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Ohyama, H., Hongyo, H., Shimizu, N., Shimizu, Y., Nishimura, F., Nakagawa, M., ... Murayama, Y. (2010). Clinical and immunological assessment of periodontal disease in japanese leprosy patients. Japanese Journal of Infectious Diseases, 63(6), 427-432.

Clinical and immunological assessment of periodontal disease in japanese leprosy patients. / Ohyama, Hideki; Hongyo, Hiroshi; Shimizu, Naoko; Shimizu, Yoshikazu; Nishimura, Fusanori; Nakagawa, Masatsugu; Arai, Hideo; Kato-Kogoe, Nahoko; Terada, Nobuyuki; Nagai, Atsushi; Takashiba, Shogo; Kurihara, Hidemi; Nomura, Yoshio; Murayama, Yoji.

In: Japanese Journal of Infectious Diseases, Vol. 63, No. 6, 06.12.2010, p. 427-432.

Research output: Contribution to journalArticle

Ohyama, H, Hongyo, H, Shimizu, N, Shimizu, Y, Nishimura, F, Nakagawa, M, Arai, H, Kato-Kogoe, N, Terada, N, Nagai, A, Takashiba, S, Kurihara, H, Nomura, Y & Murayama, Y 2010, 'Clinical and immunological assessment of periodontal disease in japanese leprosy patients', Japanese Journal of Infectious Diseases, vol. 63, no. 6, pp. 427-432.
Ohyama, Hideki ; Hongyo, Hiroshi ; Shimizu, Naoko ; Shimizu, Yoshikazu ; Nishimura, Fusanori ; Nakagawa, Masatsugu ; Arai, Hideo ; Kato-Kogoe, Nahoko ; Terada, Nobuyuki ; Nagai, Atsushi ; Takashiba, Shogo ; Kurihara, Hidemi ; Nomura, Yoshio ; Murayama, Yoji. / Clinical and immunological assessment of periodontal disease in japanese leprosy patients. In: Japanese Journal of Infectious Diseases. 2010 ; Vol. 63, No. 6. pp. 427-432.
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