Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas: A Nationwide Multicenter Study in Japan

Keiji Hanada, Keisuke Kurihara, Takao Itoi, Akio Katanuma, Tamito Sasaki, Kazuo Hara, Masafumi Nakamura, Wataru Kimura, Yutaka Suzuki, Masanori Sugiyama, Nobuyuki Ohike, Noriyoshi Fukushima, Michio Shimizu, Kousei Ishigami, Toshifumi Gabata, Kazuichi Okazaki

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Abstract

The aim of this study was to evaluate the clinicopathological features of solid pseudopapillary neoplasms (SPNs). Methods In this retrospective study, 288 SPNs were analyzed. Results Overall, 214 patients (74%) were female. Distant metastases occurred in 4 patients, and splenic vein tumor thrombus occurred in 1 patient. Although imaging findings showed large (>2.0 cm) SPNs with clear, regular border, and heterogeneous internal structure, small SPNs appeared as almost entirely solid. Surgical resection was performed in 278 cases. The 5-year survival rate was 98.8%. Six patients had tumor recurrence after the initial resection. The detection rate in typical pathological findings was low for small SPNs. Tumor extension to the pancreatic parenchyma was detected in greater than 70% of the cases. Tumor invasion to adjacent organs was detected in 13 cases. One was given a diagnosis of apparent high-grade malignant transformation. Conclusions The proportion of male cases was higher than that in previous studies, and there were statistically significant differences in the onset age and tumor diameter between male and female patients. Therefore, women seemed to have an early occurrence of SPNs, suggesting a difference in the developmental stage between men and women. Images and pathological findings of SPNs varied according to tumor size. Our findings indicated that SPN patients have excellent survival after margin-negative surgical resection.

Original languageEnglish
Pages (from-to)1019-1026
Number of pages8
JournalPancreas
Volume47
Issue number8
DOIs
Publication statusPublished - Sep 1 2018

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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    Hanada, K., Kurihara, K., Itoi, T., Katanuma, A., Sasaki, T., Hara, K., Nakamura, M., Kimura, W., Suzuki, Y., Sugiyama, M., Ohike, N., Fukushima, N., Shimizu, M., Ishigami, K., Gabata, T., & Okazaki, K. (2018). Clinical and Pathological Features of Solid Pseudopapillary Neoplasms of the Pancreas: A Nationwide Multicenter Study in Japan. Pancreas, 47(8), 1019-1026. https://doi.org/10.1097/MPA.0000000000001114