[Clinical aspects of 41 cases performed challenge test with immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA)].

Akiko Sugiyama, Reiko Kishikawa, Terufumi Shimoda, Haruko Nishie, Kiyotaka Shimada, Tomoaki Iwanaga, Masutaka Furue, Sankei Nishima

Research output: Contribution to journalArticle

Abstract

Immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA) supplemented soap has been a serious social issue. We investigated the significance of challenge test and other tests not only to diagnose HWP-IWA but to know the symptoms of each patients. From January 2010 to June 2012, we performed challenge test in 41 cases with positive prick test of Glupearl 19S®, a major allergic HWP found in Cha no Shizuku®. Thirty nine of 41 cases were challenge test positive. In two patients who showed positive skin prick test but negative for challenge test, titer of specific IgE antibody and/or basophil histamine release test against Glupearl 19S® revealed positive reaction. Challenge test is not included in indispensable examinations for the diagnosis of HWP-IWA in the recommended guidelines. However, challenge test is still a useful tool for assessing actual severity of each patient's symptoms and determining the timing of cessation of wheat avoidance. In addition, combined check-up with several laboratory examination and challenge test may help appropriate diagnosis of HWP-IWA.

Original languageEnglish
Pages (from-to)775-786
Number of pages12
JournalJapanese Journal of Allergology
Volume63
Issue number6
Publication statusPublished - 2014

Fingerprint

Wheat Hypersensitivity
Triticum
Soaps
Proteins
Basophils
Histamine Release
Skin Tests
Immunoglobulin E
Guidelines
Antibodies
Glupearl 19S

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Sugiyama, A., Kishikawa, R., Shimoda, T., Nishie, H., Shimada, K., Iwanaga, T., ... Nishima, S. (2014). [Clinical aspects of 41 cases performed challenge test with immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA)]. Japanese Journal of Allergology, 63(6), 775-786.

[Clinical aspects of 41 cases performed challenge test with immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA)]. / Sugiyama, Akiko; Kishikawa, Reiko; Shimoda, Terufumi; Nishie, Haruko; Shimada, Kiyotaka; Iwanaga, Tomoaki; Furue, Masutaka; Nishima, Sankei.

In: Japanese Journal of Allergology, Vol. 63, No. 6, 2014, p. 775-786.

Research output: Contribution to journalArticle

Sugiyama, A, Kishikawa, R, Shimoda, T, Nishie, H, Shimada, K, Iwanaga, T, Furue, M & Nishima, S 2014, '[Clinical aspects of 41 cases performed challenge test with immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA)].', Japanese Journal of Allergology, vol. 63, no. 6, pp. 775-786.
Sugiyama, Akiko ; Kishikawa, Reiko ; Shimoda, Terufumi ; Nishie, Haruko ; Shimada, Kiyotaka ; Iwanaga, Tomoaki ; Furue, Masutaka ; Nishima, Sankei. / [Clinical aspects of 41 cases performed challenge test with immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA)]. In: Japanese Journal of Allergology. 2014 ; Vol. 63, No. 6. pp. 775-786.
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