Clinical aspects of 41 cases performed challenge test with immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA)

Akiko Sugiyama, Reiko Kishikawa, Terufumi Shimoda, Haruko Nishie, Kiyotaka Shimada, Tomoaki Iwanaga, Masutaka Furue, Sankei Nishima

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4 Citations (Scopus)

Abstract

Background: Immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA) supplemented soap has been a serious social issue. We investigated the significance of challenge test and other tests not only to diagnose HWP-IWA but to know the symptoms of each patients.

Methods: From January 2010 to June 2012, we performed challenge test in 41 cases with positive prick test of Glupearl 19S®, a major allergic HWP found in Cha no Shizuku®.

Results: Thirty nine of 41 cases were challengetest positive. In two patients who showed positive skin prick test but negative for challenge test, titer of specific IgE antibody and/or basophil histamine release test against Glupearl 19S® revealed positive reaction.

Conclusion: Challenge test is not included in indispensable examinations for the diagnosis of HWP-IWA in the recommended guidelines. However, challenge test is still a useful tool for assessing actual severity of each patient's symptoms and determining the timing of cessation of wheat avoidance. In addition, combined check-up with several laboratory examination and challenge test may help appropriate diagnosis of HWP-IWA.

Original languageEnglish
Pages (from-to)775-786
Number of pages12
JournalJapanese Journal of Allergology
Volume63
Issue number6
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

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    Sugiyama, A., Kishikawa, R., Shimoda, T., Nishie, H., Shimada, K., Iwanaga, T., Furue, M., & Nishima, S. (2014). Clinical aspects of 41 cases performed challenge test with immediate-type wheat allergy due to hydrolyzed wheat protein (HWP-IWA). Japanese Journal of Allergology, 63(6), 775-786.