Clinical characteristics and endovascular treatment for spinal dural arteriovenous fistula in Japan: Japanese registry of neuroendovascular therapy 2 and 3

Wataro Tsuruta, Yuji Matsumaru, Koji Iihara, Tetsu Satow, Nobuyuki Sakai, Masahiro Katsumata, Hisayuki Hosoo, Masayuki Sato, Yoshiro Ito, Aiki Marushima, Mikito Hayakawa, Eiichi Ishikawa, Akira Matsumura

Research output: Contribution to journalArticle

Abstract

A subgroup analysis of spinal vascular lesions registered in the Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) and JR-NET3 was performed. About 172 analyzable cases of spinal dural arteriovenous fistula (SDAVF) were assessed, including the characteristics, treatment strategy, and treatment outcome. SDAVF was more common in middle-aged and older males. The most commonly affected area was the thoracolumbosacral region (83.7%), and most cases had a non-hemorrhagic onset (89.0%). Complete obliteration was achieved in 54.7%. Treatment-related complications occurred in three patients (7.0%). Post-treatment neurological improvement was achieved in 48.3%. The primary endpoint [modified Rankin Scale (mRS) score of 0–2 on postoperative day 30] was achieved in 60.5% of the cases. As a new discovery, the incidence of cervical SDAVF increased from 1.8% in JR-NET2 to 19.7% in JR-NET3. Compared with non-cervical SDAVF, cervical SDAVF was characterized by a higher proportion of hemorrhagic onset (P <0.01), incomplete obliteration of the shunt (P <0.01), and embolization-related complications (P = 0.01). Overall, a mRS of 0–2 on postoperative day 30 was correlated with a pre-treatment mRS of 0–2 (P <0.01) in a univariate analysis. Complete obliteration of the shunt was the only predictor of postoperative neurological improvement (P = 0.001) in a multivariate analysis. Endovascular treatment for SDAVF has been safely administered in Japan. The incidence of cervical SDAVF, which has more aggressive features, appears to be increasing. Early diagnosis and complete obliteration of the shunt are important for improving the treatment outcomes of patients with SDAVF.

Original languageEnglish
Pages (from-to)492-497
Number of pages6
JournalNeurologia medico-chirurgica
Volume59
Issue number12
DOIs
Publication statusPublished - Jan 1 2019

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Central Nervous System Vascular Malformations
Registries
Japan
Therapeutics
Incidence
Blood Vessels
Early Diagnosis
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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Clinical characteristics and endovascular treatment for spinal dural arteriovenous fistula in Japan : Japanese registry of neuroendovascular therapy 2 and 3. / Tsuruta, Wataro; Matsumaru, Yuji; Iihara, Koji; Satow, Tetsu; Sakai, Nobuyuki; Katsumata, Masahiro; Hosoo, Hisayuki; Sato, Masayuki; Ito, Yoshiro; Marushima, Aiki; Hayakawa, Mikito; Ishikawa, Eiichi; Matsumura, Akira.

In: Neurologia medico-chirurgica, Vol. 59, No. 12, 01.01.2019, p. 492-497.

Research output: Contribution to journalArticle

Tsuruta, W, Matsumaru, Y, Iihara, K, Satow, T, Sakai, N, Katsumata, M, Hosoo, H, Sato, M, Ito, Y, Marushima, A, Hayakawa, M, Ishikawa, E & Matsumura, A 2019, 'Clinical characteristics and endovascular treatment for spinal dural arteriovenous fistula in Japan: Japanese registry of neuroendovascular therapy 2 and 3', Neurologia medico-chirurgica, vol. 59, no. 12, pp. 492-497. https://doi.org/10.2176/nmc.st.2018-0218
Tsuruta, Wataro ; Matsumaru, Yuji ; Iihara, Koji ; Satow, Tetsu ; Sakai, Nobuyuki ; Katsumata, Masahiro ; Hosoo, Hisayuki ; Sato, Masayuki ; Ito, Yoshiro ; Marushima, Aiki ; Hayakawa, Mikito ; Ishikawa, Eiichi ; Matsumura, Akira. / Clinical characteristics and endovascular treatment for spinal dural arteriovenous fistula in Japan : Japanese registry of neuroendovascular therapy 2 and 3. In: Neurologia medico-chirurgica. 2019 ; Vol. 59, No. 12. pp. 492-497.
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AU - Satow, Tetsu

AU - Sakai, Nobuyuki

AU - Katsumata, Masahiro

AU - Hosoo, Hisayuki

AU - Sato, Masayuki

AU - Ito, Yoshiro

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