Clinical characteristics and outcome of Wilms tumors with a favorable histology in Japan: a report from the Study Group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan

Sachiyo Suita, Yoshiaki Kinoshita, Tatsuro Tajiri, Toshiro Hara, Masazumi Tsuneyoshi, Hiroyoshi Mizote, Hiroko Inada, Hideo Takamatsu, Yoshifumi Kawano, Yukihiro Inomata, Akira Nagasaki, Yasuharu Ono, Noritoshi Handa, Jun Okamura, Eiichi Ishii, Kiyoshi Kawakami

Research output: Contribution to journalArticle

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Abstract

Background/Purpose: Since 1996, the standard treatment of Wilms tumors in Japan has been based on the regimen of the Japanese Wilms Tumor Study. However, in Japan, there have been no reports about Wilms tumors that analyzed the clinical features and patient outcome in a large series until now. This study aims to assess the clinical characteristics of patients with Wilms tumor with a favorable histology from a retrospective standpoint in the Kyushu area in Japan and, furthermore, to analyze the historical changes of clinical features and outcome from the 1980s to the 1990s. Methods: Between 1982 and 1996, 90 cases of Wilms tumors with a favorable histology were registered in the Kyushu area. Regarding the clinical feature and outcome, they were divided into 2 groups (group A, 1982-1989, n = 50; group B, 1990-1996, n = 40). The outcome was analyzed based on the 5-year overall survival rate. Results: The clinical features (age, sex, initial symptom, location, stage) demonstrated no definite differences between group A and group B. Regarding the operation, the rate of an initial complete resection in the early stages was significantly higher in group B than in group A. All stage V cases in group B undewent a bilateral tumor biopsy instead of a radical nephrectomy as the initial operation. The 5-year overall survival rate throughout the whole period was 87.8%, whereas the rates were 84.0% for group A and 90.0% for group B (P = NS), respectively. Of particular note, the outcome of patients with stage I and stage V in group B substantially improved in comparison to that in group A. However, in advanced cases, no significant improvement in the outcome was noted. Conclusions: This is the first report about the clinical features and outcome for Wilms tumors with a favorable histology in Japan from the 1980s to the 1990s. The present study suggested that in the early-stage cases, an initially complete resection followed by standard postoperative chemotherapy substantially improved the outcome of the patients in group B. In the stage V cases, the performance of renal salvage surgery may have positively contributed to the improvement in the outcome in group B. However, in the advanced stage cases, no definite improvement was noted. In the future, an improved efficacy of the treatments for Wilms tumors based on the standard protocol established by the Japanese Wilms Tumor Study in 1996 is expected in Japan.

Original languageEnglish
Pages (from-to)1501-1505
Number of pages5
JournalJournal of Pediatric Surgery
Volume41
Issue number9
DOIs
Publication statusPublished - Sep 1 2006

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Wilms Tumor
Histology
Japan
Pediatrics
Neoplasms
Survival Rate
Nephrectomy
Kidney
Biopsy
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Clinical characteristics and outcome of Wilms tumors with a favorable histology in Japan : a report from the Study Group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan. / Suita, Sachiyo; Kinoshita, Yoshiaki; Tajiri, Tatsuro; Hara, Toshiro; Tsuneyoshi, Masazumi; Mizote, Hiroyoshi; Inada, Hiroko; Takamatsu, Hideo; Kawano, Yoshifumi; Inomata, Yukihiro; Nagasaki, Akira; Ono, Yasuharu; Handa, Noritoshi; Okamura, Jun; Ishii, Eiichi; Kawakami, Kiyoshi.

In: Journal of Pediatric Surgery, Vol. 41, No. 9, 01.09.2006, p. 1501-1505.

Research output: Contribution to journalArticle

Suita, S, Kinoshita, Y, Tajiri, T, Hara, T, Tsuneyoshi, M, Mizote, H, Inada, H, Takamatsu, H, Kawano, Y, Inomata, Y, Nagasaki, A, Ono, Y, Handa, N, Okamura, J, Ishii, E & Kawakami, K 2006, 'Clinical characteristics and outcome of Wilms tumors with a favorable histology in Japan: a report from the Study Group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan', Journal of Pediatric Surgery, vol. 41, no. 9, pp. 1501-1505. https://doi.org/10.1016/j.jpedsurg.2006.05.008
Suita, Sachiyo ; Kinoshita, Yoshiaki ; Tajiri, Tatsuro ; Hara, Toshiro ; Tsuneyoshi, Masazumi ; Mizote, Hiroyoshi ; Inada, Hiroko ; Takamatsu, Hideo ; Kawano, Yoshifumi ; Inomata, Yukihiro ; Nagasaki, Akira ; Ono, Yasuharu ; Handa, Noritoshi ; Okamura, Jun ; Ishii, Eiichi ; Kawakami, Kiyoshi. / Clinical characteristics and outcome of Wilms tumors with a favorable histology in Japan : a report from the Study Group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan. In: Journal of Pediatric Surgery. 2006 ; Vol. 41, No. 9. pp. 1501-1505.
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abstract = "Background/Purpose: Since 1996, the standard treatment of Wilms tumors in Japan has been based on the regimen of the Japanese Wilms Tumor Study. However, in Japan, there have been no reports about Wilms tumors that analyzed the clinical features and patient outcome in a large series until now. This study aims to assess the clinical characteristics of patients with Wilms tumor with a favorable histology from a retrospective standpoint in the Kyushu area in Japan and, furthermore, to analyze the historical changes of clinical features and outcome from the 1980s to the 1990s. Methods: Between 1982 and 1996, 90 cases of Wilms tumors with a favorable histology were registered in the Kyushu area. Regarding the clinical feature and outcome, they were divided into 2 groups (group A, 1982-1989, n = 50; group B, 1990-1996, n = 40). The outcome was analyzed based on the 5-year overall survival rate. Results: The clinical features (age, sex, initial symptom, location, stage) demonstrated no definite differences between group A and group B. Regarding the operation, the rate of an initial complete resection in the early stages was significantly higher in group B than in group A. All stage V cases in group B undewent a bilateral tumor biopsy instead of a radical nephrectomy as the initial operation. The 5-year overall survival rate throughout the whole period was 87.8{\%}, whereas the rates were 84.0{\%} for group A and 90.0{\%} for group B (P = NS), respectively. Of particular note, the outcome of patients with stage I and stage V in group B substantially improved in comparison to that in group A. However, in advanced cases, no significant improvement in the outcome was noted. Conclusions: This is the first report about the clinical features and outcome for Wilms tumors with a favorable histology in Japan from the 1980s to the 1990s. The present study suggested that in the early-stage cases, an initially complete resection followed by standard postoperative chemotherapy substantially improved the outcome of the patients in group B. In the stage V cases, the performance of renal salvage surgery may have positively contributed to the improvement in the outcome in group B. However, in the advanced stage cases, no definite improvement was noted. In the future, an improved efficacy of the treatments for Wilms tumors based on the standard protocol established by the Japanese Wilms Tumor Study in 1996 is expected in Japan.",
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T1 - Clinical characteristics and outcome of Wilms tumors with a favorable histology in Japan

T2 - a report from the Study Group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan

AU - Suita, Sachiyo

AU - Kinoshita, Yoshiaki

AU - Tajiri, Tatsuro

AU - Hara, Toshiro

AU - Tsuneyoshi, Masazumi

AU - Mizote, Hiroyoshi

AU - Inada, Hiroko

AU - Takamatsu, Hideo

AU - Kawano, Yoshifumi

AU - Inomata, Yukihiro

AU - Nagasaki, Akira

AU - Ono, Yasuharu

AU - Handa, Noritoshi

AU - Okamura, Jun

AU - Ishii, Eiichi

AU - Kawakami, Kiyoshi

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Background/Purpose: Since 1996, the standard treatment of Wilms tumors in Japan has been based on the regimen of the Japanese Wilms Tumor Study. However, in Japan, there have been no reports about Wilms tumors that analyzed the clinical features and patient outcome in a large series until now. This study aims to assess the clinical characteristics of patients with Wilms tumor with a favorable histology from a retrospective standpoint in the Kyushu area in Japan and, furthermore, to analyze the historical changes of clinical features and outcome from the 1980s to the 1990s. Methods: Between 1982 and 1996, 90 cases of Wilms tumors with a favorable histology were registered in the Kyushu area. Regarding the clinical feature and outcome, they were divided into 2 groups (group A, 1982-1989, n = 50; group B, 1990-1996, n = 40). The outcome was analyzed based on the 5-year overall survival rate. Results: The clinical features (age, sex, initial symptom, location, stage) demonstrated no definite differences between group A and group B. Regarding the operation, the rate of an initial complete resection in the early stages was significantly higher in group B than in group A. All stage V cases in group B undewent a bilateral tumor biopsy instead of a radical nephrectomy as the initial operation. The 5-year overall survival rate throughout the whole period was 87.8%, whereas the rates were 84.0% for group A and 90.0% for group B (P = NS), respectively. Of particular note, the outcome of patients with stage I and stage V in group B substantially improved in comparison to that in group A. However, in advanced cases, no significant improvement in the outcome was noted. Conclusions: This is the first report about the clinical features and outcome for Wilms tumors with a favorable histology in Japan from the 1980s to the 1990s. The present study suggested that in the early-stage cases, an initially complete resection followed by standard postoperative chemotherapy substantially improved the outcome of the patients in group B. In the stage V cases, the performance of renal salvage surgery may have positively contributed to the improvement in the outcome in group B. However, in the advanced stage cases, no definite improvement was noted. In the future, an improved efficacy of the treatments for Wilms tumors based on the standard protocol established by the Japanese Wilms Tumor Study in 1996 is expected in Japan.

AB - Background/Purpose: Since 1996, the standard treatment of Wilms tumors in Japan has been based on the regimen of the Japanese Wilms Tumor Study. However, in Japan, there have been no reports about Wilms tumors that analyzed the clinical features and patient outcome in a large series until now. This study aims to assess the clinical characteristics of patients with Wilms tumor with a favorable histology from a retrospective standpoint in the Kyushu area in Japan and, furthermore, to analyze the historical changes of clinical features and outcome from the 1980s to the 1990s. Methods: Between 1982 and 1996, 90 cases of Wilms tumors with a favorable histology were registered in the Kyushu area. Regarding the clinical feature and outcome, they were divided into 2 groups (group A, 1982-1989, n = 50; group B, 1990-1996, n = 40). The outcome was analyzed based on the 5-year overall survival rate. Results: The clinical features (age, sex, initial symptom, location, stage) demonstrated no definite differences between group A and group B. Regarding the operation, the rate of an initial complete resection in the early stages was significantly higher in group B than in group A. All stage V cases in group B undewent a bilateral tumor biopsy instead of a radical nephrectomy as the initial operation. The 5-year overall survival rate throughout the whole period was 87.8%, whereas the rates were 84.0% for group A and 90.0% for group B (P = NS), respectively. Of particular note, the outcome of patients with stage I and stage V in group B substantially improved in comparison to that in group A. However, in advanced cases, no significant improvement in the outcome was noted. Conclusions: This is the first report about the clinical features and outcome for Wilms tumors with a favorable histology in Japan from the 1980s to the 1990s. The present study suggested that in the early-stage cases, an initially complete resection followed by standard postoperative chemotherapy substantially improved the outcome of the patients in group B. In the stage V cases, the performance of renal salvage surgery may have positively contributed to the improvement in the outcome in group B. However, in the advanced stage cases, no definite improvement was noted. In the future, an improved efficacy of the treatments for Wilms tumors based on the standard protocol established by the Japanese Wilms Tumor Study in 1996 is expected in Japan.

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