Clinical characteristics of resistant hypertension evaluated by ambulatory blood pressure monitoring

Yasuo Kansui, Kiyoshi Matsumura, Haruko Kida, Satoko Sakata, Toshio Ohtsubo, Ai Ibaraki, Takanari Kitazono

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Strict control of blood pressure is important to prevent cardiovascular disease, although it is sometimes difficult to decrease blood pressure to target levels. The aim of this study was to investigate the clinical characteristics of resistant hypertension evaluated by ambulatory blood pressure monitoring. One hundred in-hospital patients, whose 24-hour average blood pressure was higher than 130/80ommHg even after treatment with more than three antihypertensive drugs, were included in the present analysis. Circadian variation of blood pressure was evaluated by nocturnal fall in systolic blood pressure. Average blood pressures of all patients were high in both daytime and nighttime, 150.0/82.9 and 143.8/78.2ommHg, respectively. Twenty patients had been treated with hemodialysis or peritoneal dialysis. In 63 patients out of the other 80 patients (79%), estimated glomerular filtration rate (eGFR) was also decreased (<60omL/min/1.73oom2). The patients classified into dipper, non-dipper, riser and extreme-dipper were 20%, 43%, 34% and 3%, respectively. In addition, in 17 patients whose eGFR was preserved, 12 patients showed a non-dipper or riser pattern, suggesting that it was difficult to account for this altered circadian blood pressure variation only by renal dysfunction. These results show that a large number of the patients with resistant hypertension suffered from renal dysfunction, although it was difficult to explain altered circadian blood pressure variation based on renal dysfunction alone.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalClinical and Experimental Hypertension
Volume36
Issue number7
DOIs
Publication statusPublished - Jan 1 2014

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Ambulatory Blood Pressure Monitoring
Hypertension
Blood Pressure
Glomerular Filtration Rate
Kidney
Renal Hypertension
Peritoneal Dialysis
Antihypertensive Agents
Renal Dialysis
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

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Clinical characteristics of resistant hypertension evaluated by ambulatory blood pressure monitoring. / Kansui, Yasuo; Matsumura, Kiyoshi; Kida, Haruko; Sakata, Satoko; Ohtsubo, Toshio; Ibaraki, Ai; Kitazono, Takanari.

In: Clinical and Experimental Hypertension, Vol. 36, No. 7, 01.01.2014, p. 454-458.

Research output: Contribution to journalArticle

Kansui, Yasuo ; Matsumura, Kiyoshi ; Kida, Haruko ; Sakata, Satoko ; Ohtsubo, Toshio ; Ibaraki, Ai ; Kitazono, Takanari. / Clinical characteristics of resistant hypertension evaluated by ambulatory blood pressure monitoring. In: Clinical and Experimental Hypertension. 2014 ; Vol. 36, No. 7. pp. 454-458.
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