Clinical Characteristics of Transient Ischemic Attack Patients with Atrial Fibrillation

Analyses of a Multicenter Retrospective Study

Yuka Hama, Toshiyuki Uehara, Tomoyuki Ohara, Kazumi Kimura, Yasushi Okada, Yasuhiro Hasegawa, Norio Tanahashi, Akifumi Suzuki, Shigeharu Takagi, Jyoji Nakagawara, Kazumasa Arii, Shinji Nagahiro, Kuniaki Ogasawara, Takehiko Nagao, Shinichiro Uchiyama, Masayasu Matsumoto, Koji Iihara, Kazunori Toyoda, Kazuo Minematsu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: Atrial fibrillation (AF) is an important risk factor for transient ischemic attack (TIA). However, little is known about the characteristics of TIA patients with AF. This study investigated the characteristics of such patients, using data from a retrospective, observational, multicenter study.

METHODS: TIA patients admitted to 13 stroke centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between patients with and without AF (AF and non-AF groups).

RESULTS: A total of 464 patients (292 men; mean age 68.5 ± 13.2 years) were registered. Of these, 79 patients (17%) had AF. Patients in the AF group were older (73.9 ± 9.1 vs. 67.4 ± 13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and aphasia (9 vs. 3%, p = 0.007) than patients in the non-AF group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion ≥15 mm (11 vs. 4%, p = 0.006), and a single lesion ≥15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the AF group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion ≥15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of AF.

CONCLUSIONS: In this study, 17% of our TIA patients had AF. We found an association between the acute ischemic lesion pattern on DWI of a single lesion ≥15 mm and AF in TIA patients. These results might lead to a better diagnosis of TIA patients with AF.

Original languageEnglish
Pages (from-to)84-90
Number of pages7
JournalCerebrovascular diseases extra
Volume5
Issue number2
DOIs
Publication statusPublished - May 1 2015
Externally publishedYes

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Transient Ischemic Attack
Atrial Fibrillation
Multicenter Studies
Retrospective Studies
Odds Ratio
Confidence Intervals
Aphasia
Consciousness
Observational Studies
Japan
Logistic Models
Stroke
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Clinical Characteristics of Transient Ischemic Attack Patients with Atrial Fibrillation : Analyses of a Multicenter Retrospective Study. / Hama, Yuka; Uehara, Toshiyuki; Ohara, Tomoyuki; Kimura, Kazumi; Okada, Yasushi; Hasegawa, Yasuhiro; Tanahashi, Norio; Suzuki, Akifumi; Takagi, Shigeharu; Nakagawara, Jyoji; Arii, Kazumasa; Nagahiro, Shinji; Ogasawara, Kuniaki; Nagao, Takehiko; Uchiyama, Shinichiro; Matsumoto, Masayasu; Iihara, Koji; Toyoda, Kazunori; Minematsu, Kazuo.

In: Cerebrovascular diseases extra, Vol. 5, No. 2, 01.05.2015, p. 84-90.

Research output: Contribution to journalArticle

Hama, Y, Uehara, T, Ohara, T, Kimura, K, Okada, Y, Hasegawa, Y, Tanahashi, N, Suzuki, A, Takagi, S, Nakagawara, J, Arii, K, Nagahiro, S, Ogasawara, K, Nagao, T, Uchiyama, S, Matsumoto, M, Iihara, K, Toyoda, K & Minematsu, K 2015, 'Clinical Characteristics of Transient Ischemic Attack Patients with Atrial Fibrillation: Analyses of a Multicenter Retrospective Study', Cerebrovascular diseases extra, vol. 5, no. 2, pp. 84-90. https://doi.org/10.1159/000434689
Hama, Yuka ; Uehara, Toshiyuki ; Ohara, Tomoyuki ; Kimura, Kazumi ; Okada, Yasushi ; Hasegawa, Yasuhiro ; Tanahashi, Norio ; Suzuki, Akifumi ; Takagi, Shigeharu ; Nakagawara, Jyoji ; Arii, Kazumasa ; Nagahiro, Shinji ; Ogasawara, Kuniaki ; Nagao, Takehiko ; Uchiyama, Shinichiro ; Matsumoto, Masayasu ; Iihara, Koji ; Toyoda, Kazunori ; Minematsu, Kazuo. / Clinical Characteristics of Transient Ischemic Attack Patients with Atrial Fibrillation : Analyses of a Multicenter Retrospective Study. In: Cerebrovascular diseases extra. 2015 ; Vol. 5, No. 2. pp. 84-90.
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T1 - Clinical Characteristics of Transient Ischemic Attack Patients with Atrial Fibrillation

T2 - Analyses of a Multicenter Retrospective Study

AU - Hama, Yuka

AU - Uehara, Toshiyuki

AU - Ohara, Tomoyuki

AU - Kimura, Kazumi

AU - Okada, Yasushi

AU - Hasegawa, Yasuhiro

AU - Tanahashi, Norio

AU - Suzuki, Akifumi

AU - Takagi, Shigeharu

AU - Nakagawara, Jyoji

AU - Arii, Kazumasa

AU - Nagahiro, Shinji

AU - Ogasawara, Kuniaki

AU - Nagao, Takehiko

AU - Uchiyama, Shinichiro

AU - Matsumoto, Masayasu

AU - Iihara, Koji

AU - Toyoda, Kazunori

AU - Minematsu, Kazuo

PY - 2015/5/1

Y1 - 2015/5/1

N2 - BACKGROUND: Atrial fibrillation (AF) is an important risk factor for transient ischemic attack (TIA). However, little is known about the characteristics of TIA patients with AF. This study investigated the characteristics of such patients, using data from a retrospective, observational, multicenter study.METHODS: TIA patients admitted to 13 stroke centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between patients with and without AF (AF and non-AF groups).RESULTS: A total of 464 patients (292 men; mean age 68.5 ± 13.2 years) were registered. Of these, 79 patients (17%) had AF. Patients in the AF group were older (73.9 ± 9.1 vs. 67.4 ± 13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and aphasia (9 vs. 3%, p = 0.007) than patients in the non-AF group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion ≥15 mm (11 vs. 4%, p = 0.006), and a single lesion ≥15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the AF group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion ≥15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of AF.CONCLUSIONS: In this study, 17% of our TIA patients had AF. We found an association between the acute ischemic lesion pattern on DWI of a single lesion ≥15 mm and AF in TIA patients. These results might lead to a better diagnosis of TIA patients with AF.

AB - BACKGROUND: Atrial fibrillation (AF) is an important risk factor for transient ischemic attack (TIA). However, little is known about the characteristics of TIA patients with AF. This study investigated the characteristics of such patients, using data from a retrospective, observational, multicenter study.METHODS: TIA patients admitted to 13 stroke centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between patients with and without AF (AF and non-AF groups).RESULTS: A total of 464 patients (292 men; mean age 68.5 ± 13.2 years) were registered. Of these, 79 patients (17%) had AF. Patients in the AF group were older (73.9 ± 9.1 vs. 67.4 ± 13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and aphasia (9 vs. 3%, p = 0.007) than patients in the non-AF group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion ≥15 mm (11 vs. 4%, p = 0.006), and a single lesion ≥15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the AF group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion ≥15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of AF.CONCLUSIONS: In this study, 17% of our TIA patients had AF. We found an association between the acute ischemic lesion pattern on DWI of a single lesion ≥15 mm and AF in TIA patients. These results might lead to a better diagnosis of TIA patients with AF.

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