Clinical efulness of Measurement of Serum Fructosamine in Diabetics: Influence of Renal Failure, Liver Cirrhosis, and Thyroid Dysfunction

Yasuhiro Sako, Fumio Umeda, Toshihiko Hashimoto, Toyoshi Inoguchi, Kazuo Mimura, Makoto Kunisaki, Yuji Tajiri, Hidehiro Ishii, Tsukasa Yamashita, Teruaki Yamauchi, Hajime Nawata

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Measurement of serum fructosamine (FRA) by means of a Roche kit is a simple and reliable method for estimating glycosylated serum proteins. The level of FRA can be affected by hyperglycemia in diabetics and an abnormal metabolic state of serum proteins such as albumin in patients with renal failure, liver cirrhosis, and thyroid dysfunction. We measured FRA in diabetics and these patients. The average FRA level was 2.58 ± 0.08 (mean ± SE) mmol/l in the normal controls (n=18), 4.60±0.67 in patients with IDDM (n=8), and 3.61±0.10 in patients with NIDDM (n=63). In the patients with non-diabetic renal failure, while the FRA level was significantly (p<0.05) low, FRA corrected by total protein concentration was not different from that of the normal controls. The FRA level in liver cirrhosis without hyperbilirubinemia was not significantly different from that of normal controls. In the patients with thyroid disease, the FRA level was 2.08±0.03 in hyperthyroidism and 3. 11 ±0.07 in hypothyroidism. Moreover, the FRA level was negatively correlated with the thyroid hormones T3 and T4 (p<0.001). It is concluded that measurement of FRA is clinically useful for evaluating short-term glycemic control in diabetics even when there is complicating nephropathy or liver cirrhosis. However, its level in diabetic patients with hyperbilirubinemia or thyroid dysfunction must be cautiously interpreted.

Original languageEnglish
Pages (from-to)929-935
Number of pages7
JournalJournal of the Japan Diabetes Society
Volume31
Issue number12
DOIs
Publication statusPublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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