For the purpose of examining the efficacy, safety and usefulness of sertraline hydrochloride, a double blind group comparison study was performed in 218 patients with depression or in a depressive state using trazodone hydrochloride as a control drug. Sertraline hydrochloride (Group S) at a dose of 25 75 mg/day or trazodone hydrochloride (Group T) at a dose of 75 225 mg/day was administered. The improvement rate including 'unevaluable cases' was 57.8% in Group S and 54.3% in Group T, by which the equivalence of sertraline hydrochloride to trazodone hydrochloride was ascertained. The incidence of adverse reactions was 32.7% in Group S and 34.3% in Group T, with no significant difference in the rate between the two groups. The usefulness rate including unevaluable cases was 46.7% in Group S and 45.1% in Group T. The rate not including the unevaluables was 51.5% in Group S and 47.4% in Group T. The equivalence of sertraline hydrochloride to trazodone hydrochloride in the rate was ascertained regardless whether with or without the unevaluable cases. These results demonstrated that the usefulness of sertraline hydrochloride is equal or superior to that of trazodone hydrochloride.
|Number of pages||20|
|Journal||Japanese Journal of Neuropsychopharmacology|
|Publication status||Published - Jan 1 1997|
All Science Journal Classification (ASJC) codes
- Clinical Psychology
- Psychiatry and Mental health
- Pharmacology (medical)