Clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis

a review

takashi maehara, S. Pillai, J. H. Stone, Seiji Nakamura

Research output: Contribution to journalReview article

Abstract

Immunoglobulin G4-related disease (IgG4-RD), recognized only recently as a single diagnostic entity, is a chronic inflammatory condition of unknown etiology. The diagnosis of IgG4-RD relies heavily on histopathological analysis and the correlation of histology findings with clinical, serological, and radiological data. CD4+ T and B cells, including IgG4-expressing plasmablasts, constitute the major inflammatory cell populations in IgG4-RD and are believed to cause organ damage and tissue fibrosis. Patients with IgG4-RD, who have active, untreated disease, exhibit marked expansion of IgG4-secreting plasmablasts in the blood. Important mechanistic insights correlated with the pathogenesis of IgG4-RD have been disclosed in recent years through the application of novel molecular biology approaches, including next-generation and single-cell RNA sequencing. Exploration of the interactions between these CD4+ T cells and cells of the B lymphocyte lineage is critical to understanding the pathophysiology of IgG4-RD. The establishment of pathogenic T cell clones and the identification of antigens specific to these clones constitute the first steps in determining the pathogenesis of this disease. This review focuses on clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis, from a perspective suitable for oral and maxillofacial surgeons.

Original languageEnglish
Pages (from-to)908-916
Number of pages9
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume48
Issue number7
DOIs
Publication statusPublished - Jul 1 2019

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Dacryocystitis
Sialadenitis
Immunoglobulin G
Immunoglobulins
T-Lymphocytes
B-Lymphocytes
Clone Cells
RNA Sequence Analysis
Molecular Biology
Histology
Fibrosis
Antigens

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Clinical features and mechanistic insights regarding IgG4-related dacryoadenitis and sialoadenitis : a review. / maehara, takashi; Pillai, S.; Stone, J. H.; Nakamura, Seiji.

In: International Journal of Oral and Maxillofacial Surgery, Vol. 48, No. 7, 01.07.2019, p. 908-916.

Research output: Contribution to journalReview article

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