Clinical features of selenium deficiency in infants receiving long-term nutritional support

Kouji Masumoto, Kouji Nagata, Mayumi Higashi, Takanori Nakatsuji, Toru Uesugi, Yukiko Takahashi, Yuko Nishimoto, Junko Kitajima, Shunji Hikino, Toshiro Hara, Kazue Nakashima, Kazuhiro Nakashima, Ryozo Oishi, Tomoaki Taguchi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: Selenium deficiency is a known complication in patients requiring long-term nutritional support; however, the clinical features of selenium deficiency in infants have not been completely described. We describe the clinical features of selenium deficiency in infants. Methods: Six infants with selenium deficiency were studied retrospectively, with a focus on the period of nutritional support, the clinical symptoms, and the chronologic changes in serum selenium concentrations before and after the administration of selenite. Results: The onset of selenium deficiency in five patients occurred at <6 mo of age; selenium deficiency occurred in one patient 14 mo after birth. One patient received parenteral nutrition for 15 mo after birth; the other five patients primarily received an elemental diet for 2-6 mo. In all patients, growth retardation and alopecia with pseudoalbinism were the characteristic symptoms of selenium deficiency. At the time of diagnosis, the serum selenium level in four patients was <2.0 μg/dL and serum selenium levels in two patients were 3.2 and 3.3 μg/dL, respectively. The resolution of hair symptoms corresponded to the level of serum selenium after 1-2 mo and a rapid improvement in growth occurred in all patients after the administration of selenite. Conclusion: The early clinical symptoms of selenium deficiency in infants include growth retardation and alopecia with pseudoalbinism, which are reversible if the patients are treated with adequate amounts of selenite. Clinicians who manage infants receiving long-term nutritional support, including an elemental diet, should be aware of the symptoms associated with selenium deficiency.

Original languageEnglish
Pages (from-to)782-787
Number of pages6
JournalNutrition
Volume23
Issue number11-12
DOIs
Publication statusPublished - Nov 1 2007

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Nutritional Support
Selenium
Selenious Acid
Formulated Food
Alopecia
Serum
Growth
Parturition
Parenteral Nutrition
Hair

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Masumoto, K., Nagata, K., Higashi, M., Nakatsuji, T., Uesugi, T., Takahashi, Y., ... Taguchi, T. (2007). Clinical features of selenium deficiency in infants receiving long-term nutritional support. Nutrition, 23(11-12), 782-787. https://doi.org/10.1016/j.nut.2007.08.001

Clinical features of selenium deficiency in infants receiving long-term nutritional support. / Masumoto, Kouji; Nagata, Kouji; Higashi, Mayumi; Nakatsuji, Takanori; Uesugi, Toru; Takahashi, Yukiko; Nishimoto, Yuko; Kitajima, Junko; Hikino, Shunji; Hara, Toshiro; Nakashima, Kazue; Nakashima, Kazuhiro; Oishi, Ryozo; Taguchi, Tomoaki.

In: Nutrition, Vol. 23, No. 11-12, 01.11.2007, p. 782-787.

Research output: Contribution to journalArticle

Masumoto, K, Nagata, K, Higashi, M, Nakatsuji, T, Uesugi, T, Takahashi, Y, Nishimoto, Y, Kitajima, J, Hikino, S, Hara, T, Nakashima, K, Nakashima, K, Oishi, R & Taguchi, T 2007, 'Clinical features of selenium deficiency in infants receiving long-term nutritional support', Nutrition, vol. 23, no. 11-12, pp. 782-787. https://doi.org/10.1016/j.nut.2007.08.001
Masumoto K, Nagata K, Higashi M, Nakatsuji T, Uesugi T, Takahashi Y et al. Clinical features of selenium deficiency in infants receiving long-term nutritional support. Nutrition. 2007 Nov 1;23(11-12):782-787. https://doi.org/10.1016/j.nut.2007.08.001
Masumoto, Kouji ; Nagata, Kouji ; Higashi, Mayumi ; Nakatsuji, Takanori ; Uesugi, Toru ; Takahashi, Yukiko ; Nishimoto, Yuko ; Kitajima, Junko ; Hikino, Shunji ; Hara, Toshiro ; Nakashima, Kazue ; Nakashima, Kazuhiro ; Oishi, Ryozo ; Taguchi, Tomoaki. / Clinical features of selenium deficiency in infants receiving long-term nutritional support. In: Nutrition. 2007 ; Vol. 23, No. 11-12. pp. 782-787.
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abstract = "Objective: Selenium deficiency is a known complication in patients requiring long-term nutritional support; however, the clinical features of selenium deficiency in infants have not been completely described. We describe the clinical features of selenium deficiency in infants. Methods: Six infants with selenium deficiency were studied retrospectively, with a focus on the period of nutritional support, the clinical symptoms, and the chronologic changes in serum selenium concentrations before and after the administration of selenite. Results: The onset of selenium deficiency in five patients occurred at <6 mo of age; selenium deficiency occurred in one patient 14 mo after birth. One patient received parenteral nutrition for 15 mo after birth; the other five patients primarily received an elemental diet for 2-6 mo. In all patients, growth retardation and alopecia with pseudoalbinism were the characteristic symptoms of selenium deficiency. At the time of diagnosis, the serum selenium level in four patients was <2.0 μg/dL and serum selenium levels in two patients were 3.2 and 3.3 μg/dL, respectively. The resolution of hair symptoms corresponded to the level of serum selenium after 1-2 mo and a rapid improvement in growth occurred in all patients after the administration of selenite. Conclusion: The early clinical symptoms of selenium deficiency in infants include growth retardation and alopecia with pseudoalbinism, which are reversible if the patients are treated with adequate amounts of selenite. Clinicians who manage infants receiving long-term nutritional support, including an elemental diet, should be aware of the symptoms associated with selenium deficiency.",
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AU - Takahashi, Yukiko

AU - Nishimoto, Yuko

AU - Kitajima, Junko

AU - Hikino, Shunji

AU - Hara, Toshiro

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AU - Oishi, Ryozo

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N2 - Objective: Selenium deficiency is a known complication in patients requiring long-term nutritional support; however, the clinical features of selenium deficiency in infants have not been completely described. We describe the clinical features of selenium deficiency in infants. Methods: Six infants with selenium deficiency were studied retrospectively, with a focus on the period of nutritional support, the clinical symptoms, and the chronologic changes in serum selenium concentrations before and after the administration of selenite. Results: The onset of selenium deficiency in five patients occurred at <6 mo of age; selenium deficiency occurred in one patient 14 mo after birth. One patient received parenteral nutrition for 15 mo after birth; the other five patients primarily received an elemental diet for 2-6 mo. In all patients, growth retardation and alopecia with pseudoalbinism were the characteristic symptoms of selenium deficiency. At the time of diagnosis, the serum selenium level in four patients was <2.0 μg/dL and serum selenium levels in two patients were 3.2 and 3.3 μg/dL, respectively. The resolution of hair symptoms corresponded to the level of serum selenium after 1-2 mo and a rapid improvement in growth occurred in all patients after the administration of selenite. Conclusion: The early clinical symptoms of selenium deficiency in infants include growth retardation and alopecia with pseudoalbinism, which are reversible if the patients are treated with adequate amounts of selenite. Clinicians who manage infants receiving long-term nutritional support, including an elemental diet, should be aware of the symptoms associated with selenium deficiency.

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