Clinical features of the differentiated and undifferentiated types of advanced gastric carcinoma

Univariate and multivariate analyses

Sunao Moriguchi, Tatsurou Kamakura, Tomohiro Odaka, Yoshiaki Nose, Yoshihiko Maehara, Daisuke Korenaga, Keizo Sugimachi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This study was done to define clinical features for the different pathological types of advanced gastric carcinoma. One thousand one hundred three patients were identified and classified into two groups: 479 patients (43.4%) had a differentiated adenocarcinoma and 624 patients (56.6%) had an undifferentiated adenocarcinoma. Patients with the undifferentiated type were more likely to have large invasive tumors and a higher incidence of peritoneal dissemination. Conversely, the patients with the differentiated type were more likely to have a liver metastasis. Multivariate analysis, using Cox' proportional hazard model adjusted for sex, age, and other factors, suggested that tumor size was one of the seven most independent prognostic factors in patients with the undifferentiated type (relative risk = 1.01), but this parameter lost prognostic value in patients with the differentiated type. With regard to correlation between survival time and tumor size, the larger the tumor (over 10 cm), the shorter the survival time of patients with the undifferentiated type, as compared to findings in patients with the differentiated type (P < 0.01). Thus, differences in clinical characteristics, including characteristics in the individual patients, extent of tumor, distant metastasis, prognostic factors, and prognosis correlate with the histopathological type of gastric carcinoma.

Original languageEnglish
Pages (from-to)202-206
Number of pages5
JournalJournal of Surgical Oncology
Volume48
Issue number3
DOIs
Publication statusPublished - Jan 1 1991

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Stomach
Multivariate Analysis
Carcinoma
Neoplasms
Adenocarcinoma
Neoplasm Metastasis
Survival
Age Factors
Proportional Hazards Models
Liver
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Clinical features of the differentiated and undifferentiated types of advanced gastric carcinoma : Univariate and multivariate analyses. / Moriguchi, Sunao; Kamakura, Tatsurou; Odaka, Tomohiro; Nose, Yoshiaki; Maehara, Yoshihiko; Korenaga, Daisuke; Sugimachi, Keizo.

In: Journal of Surgical Oncology, Vol. 48, No. 3, 01.01.1991, p. 202-206.

Research output: Contribution to journalArticle

Moriguchi, Sunao ; Kamakura, Tatsurou ; Odaka, Tomohiro ; Nose, Yoshiaki ; Maehara, Yoshihiko ; Korenaga, Daisuke ; Sugimachi, Keizo. / Clinical features of the differentiated and undifferentiated types of advanced gastric carcinoma : Univariate and multivariate analyses. In: Journal of Surgical Oncology. 1991 ; Vol. 48, No. 3. pp. 202-206.
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