Clinical, immunological and MRI features of myelitis with atopic dermatitis (atopic myelitis)

Jun-Ichi Kira, Yuji Kawano, Izumi Horiuchi, Takeshi Yamada, Shuhei Imayama, Masutaka Furue, Kenji Yamasaki

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In order to clarify the characteristic features of myelitis with atopic dermatitis (AD), we compared the clinical, immunological and MRI findings between 14 myelitic patients with AD and 12 myelitic patients without AD. The myelitic patients with AD showed the following distinct features, compared with those without AD. (1) A preferential involvement of the cervical cord, as shown by neurologic as well as MRI examinations (14/14 vs. 5/12; P=0.0012), (2) paresthesia/dysesthesia as the predominant symptoms and a rare occurrence of definite muscle weakness (0/14 vs. 5/12; P=0.0120) and dysuria (1/14 vs. 8/12; P=0.0029), (3) a lower Expanded Disability Status Scale score (mean, 1.5 vs. 3.5; P=0.0018), (4) normal cerebrospinal fluid (CSF) findings including those for the IgG index and oligoclonal IgG bands and (5) a persistence of neurologic symptoms and MRI lesions during the follow-up periods (mean, 17 months). In addition, both the serum total IgE level and the frequency of specific IgE to Dermatophagoides farinae were significantly higher in the myelitic patients with AD (median IGE=1266 U/ml, specific IgE 14/14) than in those without AD (145 U/ml, P=0.0034 and 8/12, P=0.0331, respectively) and in 40 healthy controls (86 U/ml, P<0.0001 and 12/40, P<0.0001, respectively). Since myelitis with AD has distinct features and atopy to mite antigens appears to be the underlying cause of this condition, it may therefore be a distinct subtype of myelitis.

Original languageEnglish
Pages (from-to)56-61
Number of pages6
JournalJournal of the Neurological Sciences
Volume162
Issue number1
DOIs
Publication statusPublished - Jan 1 1999

Fingerprint

Myelitis
Atopic Dermatitis
Oligoclonal Bands
Immunoglobulin E
Paresthesia
Dermatophagoides farinae
Dysuria
Mites
Muscle Weakness
Neurologic Manifestations
Nervous System
Cerebrospinal Fluid
Immunoglobulin G
Antigens

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Clinical, immunological and MRI features of myelitis with atopic dermatitis (atopic myelitis). / Kira, Jun-Ichi; Kawano, Yuji; Horiuchi, Izumi; Yamada, Takeshi; Imayama, Shuhei; Furue, Masutaka; Yamasaki, Kenji.

In: Journal of the Neurological Sciences, Vol. 162, No. 1, 01.01.1999, p. 56-61.

Research output: Contribution to journalArticle

Kira, Jun-Ichi ; Kawano, Yuji ; Horiuchi, Izumi ; Yamada, Takeshi ; Imayama, Shuhei ; Furue, Masutaka ; Yamasaki, Kenji. / Clinical, immunological and MRI features of myelitis with atopic dermatitis (atopic myelitis). In: Journal of the Neurological Sciences. 1999 ; Vol. 162, No. 1. pp. 56-61.
@article{abd94c6a7ec146acab545506d06ad6a1,
title = "Clinical, immunological and MRI features of myelitis with atopic dermatitis (atopic myelitis)",
abstract = "In order to clarify the characteristic features of myelitis with atopic dermatitis (AD), we compared the clinical, immunological and MRI findings between 14 myelitic patients with AD and 12 myelitic patients without AD. The myelitic patients with AD showed the following distinct features, compared with those without AD. (1) A preferential involvement of the cervical cord, as shown by neurologic as well as MRI examinations (14/14 vs. 5/12; P=0.0012), (2) paresthesia/dysesthesia as the predominant symptoms and a rare occurrence of definite muscle weakness (0/14 vs. 5/12; P=0.0120) and dysuria (1/14 vs. 8/12; P=0.0029), (3) a lower Expanded Disability Status Scale score (mean, 1.5 vs. 3.5; P=0.0018), (4) normal cerebrospinal fluid (CSF) findings including those for the IgG index and oligoclonal IgG bands and (5) a persistence of neurologic symptoms and MRI lesions during the follow-up periods (mean, 17 months). In addition, both the serum total IgE level and the frequency of specific IgE to Dermatophagoides farinae were significantly higher in the myelitic patients with AD (median IGE=1266 U/ml, specific IgE 14/14) than in those without AD (145 U/ml, P=0.0034 and 8/12, P=0.0331, respectively) and in 40 healthy controls (86 U/ml, P<0.0001 and 12/40, P<0.0001, respectively). Since myelitis with AD has distinct features and atopy to mite antigens appears to be the underlying cause of this condition, it may therefore be a distinct subtype of myelitis.",
author = "Jun-Ichi Kira and Yuji Kawano and Izumi Horiuchi and Takeshi Yamada and Shuhei Imayama and Masutaka Furue and Kenji Yamasaki",
year = "1999",
month = "1",
day = "1",
doi = "10.1016/S0022-510X(98)00291-3",
language = "English",
volume = "162",
pages = "56--61",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Clinical, immunological and MRI features of myelitis with atopic dermatitis (atopic myelitis)

AU - Kira, Jun-Ichi

AU - Kawano, Yuji

AU - Horiuchi, Izumi

AU - Yamada, Takeshi

AU - Imayama, Shuhei

AU - Furue, Masutaka

AU - Yamasaki, Kenji

PY - 1999/1/1

Y1 - 1999/1/1

N2 - In order to clarify the characteristic features of myelitis with atopic dermatitis (AD), we compared the clinical, immunological and MRI findings between 14 myelitic patients with AD and 12 myelitic patients without AD. The myelitic patients with AD showed the following distinct features, compared with those without AD. (1) A preferential involvement of the cervical cord, as shown by neurologic as well as MRI examinations (14/14 vs. 5/12; P=0.0012), (2) paresthesia/dysesthesia as the predominant symptoms and a rare occurrence of definite muscle weakness (0/14 vs. 5/12; P=0.0120) and dysuria (1/14 vs. 8/12; P=0.0029), (3) a lower Expanded Disability Status Scale score (mean, 1.5 vs. 3.5; P=0.0018), (4) normal cerebrospinal fluid (CSF) findings including those for the IgG index and oligoclonal IgG bands and (5) a persistence of neurologic symptoms and MRI lesions during the follow-up periods (mean, 17 months). In addition, both the serum total IgE level and the frequency of specific IgE to Dermatophagoides farinae were significantly higher in the myelitic patients with AD (median IGE=1266 U/ml, specific IgE 14/14) than in those without AD (145 U/ml, P=0.0034 and 8/12, P=0.0331, respectively) and in 40 healthy controls (86 U/ml, P<0.0001 and 12/40, P<0.0001, respectively). Since myelitis with AD has distinct features and atopy to mite antigens appears to be the underlying cause of this condition, it may therefore be a distinct subtype of myelitis.

AB - In order to clarify the characteristic features of myelitis with atopic dermatitis (AD), we compared the clinical, immunological and MRI findings between 14 myelitic patients with AD and 12 myelitic patients without AD. The myelitic patients with AD showed the following distinct features, compared with those without AD. (1) A preferential involvement of the cervical cord, as shown by neurologic as well as MRI examinations (14/14 vs. 5/12; P=0.0012), (2) paresthesia/dysesthesia as the predominant symptoms and a rare occurrence of definite muscle weakness (0/14 vs. 5/12; P=0.0120) and dysuria (1/14 vs. 8/12; P=0.0029), (3) a lower Expanded Disability Status Scale score (mean, 1.5 vs. 3.5; P=0.0018), (4) normal cerebrospinal fluid (CSF) findings including those for the IgG index and oligoclonal IgG bands and (5) a persistence of neurologic symptoms and MRI lesions during the follow-up periods (mean, 17 months). In addition, both the serum total IgE level and the frequency of specific IgE to Dermatophagoides farinae were significantly higher in the myelitic patients with AD (median IGE=1266 U/ml, specific IgE 14/14) than in those without AD (145 U/ml, P=0.0034 and 8/12, P=0.0331, respectively) and in 40 healthy controls (86 U/ml, P<0.0001 and 12/40, P<0.0001, respectively). Since myelitis with AD has distinct features and atopy to mite antigens appears to be the underlying cause of this condition, it may therefore be a distinct subtype of myelitis.

UR - http://www.scopus.com/inward/record.url?scp=0032921562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032921562&partnerID=8YFLogxK

U2 - 10.1016/S0022-510X(98)00291-3

DO - 10.1016/S0022-510X(98)00291-3

M3 - Article

VL - 162

SP - 56

EP - 61

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1

ER -