TY - JOUR
T1 - Clinical impact of a humanized CCR4 antibody (mogamulizumab) in 14 patients with aggressive adult T-cell leukemia-lymphoma treated at a single institution during a three-year period (2012-2014)
AU - Kawano, Noriaki
AU - Kuriyama, Takuro
AU - Sonoda, Koh Hei
AU - Yoshida, Shuro
AU - Yamashita, Kiyoshi
AU - Ochiai, Hidenobu
AU - Shimoda, Kazuya
AU - Ishikawa, Fumihiko
AU - Ueda, Akira
AU - Kikuchi, Ikuo
N1 - Publisher Copyright:
© 2016 The Japanese Society of Internal Medicine.
PY - 2016
Y1 - 2016
N2 - Objective We elucidated the effectiveness of a humanized CCR4 antibody (mogamulizumab) on adult Tcell leukemia-lymphoma (ATL), which typically has a poor outcome. Methods We retrospectively analyzed 14 patients with aggressive ATL who had been treated at our institution with weekly cycles of mogamulizumab for eight weeks from 2012-2014. Results The patients (median age: 63 years old) were classified as having acute- (n=10) or lymphoma-type (n=4) ATL. The prior treatment regimens consisted of CHOP, VCAP-AMP-VECP, DeVIC and CHASE, with an average of two courses (range: 1-4). The prior disease responses were partial remission (n=3) and progressive disease (n=11). The treatment was administered in the primary refractory setting (n=8), for relapse (n= 2), or as bridging therapy before hematopoietic stem cell transplantation (n=4). The overall response rates were 64% and 43% after four and eight cycles (or after the final cycles), respectively. The median overall survival (OS), OS rate at six months and OS rate at 12 months were 66 days, 41.7% and 20.8%, respectively. All of the patients with acute-type ATL who showed a response to treatment had an early response. Notably, six of the 14 ATL patients showed somewhat prolonged survival (>100 days). However, relapse or disease progression in the peripheral blood, central nervous system, lymph nodes, skin, and/or bone occurred within a relatively short period after treatment. The adverse effects were tolerable, and included lymphopenia, cytomegalovirus infection and skin rash. Conclusion Mogamulizumab therapy resulted in an early and high remission rate and somewhat prolonged survival in patients with refractory ATL. However, the duration of remission was short, and there was early relapse and disease progression. This study may show the current impact of mogamulizumab in clinical practice.
AB - Objective We elucidated the effectiveness of a humanized CCR4 antibody (mogamulizumab) on adult Tcell leukemia-lymphoma (ATL), which typically has a poor outcome. Methods We retrospectively analyzed 14 patients with aggressive ATL who had been treated at our institution with weekly cycles of mogamulizumab for eight weeks from 2012-2014. Results The patients (median age: 63 years old) were classified as having acute- (n=10) or lymphoma-type (n=4) ATL. The prior treatment regimens consisted of CHOP, VCAP-AMP-VECP, DeVIC and CHASE, with an average of two courses (range: 1-4). The prior disease responses were partial remission (n=3) and progressive disease (n=11). The treatment was administered in the primary refractory setting (n=8), for relapse (n= 2), or as bridging therapy before hematopoietic stem cell transplantation (n=4). The overall response rates were 64% and 43% after four and eight cycles (or after the final cycles), respectively. The median overall survival (OS), OS rate at six months and OS rate at 12 months were 66 days, 41.7% and 20.8%, respectively. All of the patients with acute-type ATL who showed a response to treatment had an early response. Notably, six of the 14 ATL patients showed somewhat prolonged survival (>100 days). However, relapse or disease progression in the peripheral blood, central nervous system, lymph nodes, skin, and/or bone occurred within a relatively short period after treatment. The adverse effects were tolerable, and included lymphopenia, cytomegalovirus infection and skin rash. Conclusion Mogamulizumab therapy resulted in an early and high remission rate and somewhat prolonged survival in patients with refractory ATL. However, the duration of remission was short, and there was early relapse and disease progression. This study may show the current impact of mogamulizumab in clinical practice.
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U2 - 10.2169/internalmedicine.55.6312
DO - 10.2169/internalmedicine.55.6312
M3 - Article
C2 - 27250049
AN - SCOPUS:84971476169
VL - 55
SP - 1439
EP - 1445
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 11
ER -