Clinical impact of genetic variants of drug transporters in different ethnic groups within and across regions

Chiho Ono, Hironori Kikkawa, Akiyuki Suzuki, Misaki Suzuki, Yuichi Yamamoto, Katsuomi Ichikawa, Masato Fukae, Ichiro Ieiri

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Drug transporters, together with drug metabolic enzymes, are major determinants of drug disposition and are known to alter the response to many commonly used drugs. Substantial frequency differences for known variants exist across geographic regions for certain drug transporters. To deliver efficacious medicine with the right dose for each patient, it is important to understand the contribution of genetic variants for drug transporters. Recently, mutual pharmacokinetic data usage among Asian regions, which are thought to be relatively similar in their own genetic background, is expected to accelerate new drug applications and reduce developmental costs. Polymorphisms of drug transporters could be key factors to be considered in implementing multiethnic global clinical trials. This review addresses the current knowledge on genetic variations of major drug transporters affecting drug disposition, efficacy and toxicity, focusing on the east Asian populations, and provides insights into future directions for precision medicine and drug development in east Asia.

Original languageEnglish
Pages (from-to)1745-1764
Number of pages20
JournalPharmacogenomics
Volume14
Issue number14
DOIs
Publication statusPublished - Nov 2013

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Pharmacology

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    Ono, C., Kikkawa, H., Suzuki, A., Suzuki, M., Yamamoto, Y., Ichikawa, K., Fukae, M., & Ieiri, I. (2013). Clinical impact of genetic variants of drug transporters in different ethnic groups within and across regions. Pharmacogenomics, 14(14), 1745-1764. https://doi.org/10.2217/pgs.13.171