Clinical impact of left ventricular eccentricity index using cardiac MRI in assessment of right ventricular hemodynamics and myocardial fibrosis in congenital heart disease

Yuzo Yamasaki, Michinobu Nagao, Takeshi Kamitani, Torahiko Yamanouchi, Satoshi Kawanami, Kenichiro Yamamura, Ichiro Sakamoto, Hidetake Yabuuchi, Hiroshi Honda

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objectives: To investigate the utility of eccentricity index (EI) using cardiac cine MRI for the assessment of right ventricular (RV) hemodynamics in congenital heart disease (CHD). Methods: Fifty-five patients with CHD (32 women; mean age, 40.7 ± 20.9 years) underwent both cardiac MRI and right heart catheterization. EI was defined as the ratio of the distance between the anterior-posterior wall and the septal-lateral wall measured in the short-axis of mid-ventricular cine MRI. Correlations between EIs and RV hemodynamic parameters were analyzed. EIs were compared between patients with and without late gadolinium enhancement (LGE). Results: A strong correlation between mean pulmonary artery pressure (PAP) and systolic EI (r = 0.81, p < 0.0001) and a moderate negative correlation between diastolic EI and RV ejection fraction (EF) (r = -0.62, p < 0.0001) were observed. Receiver operating characteristic analysis revealed optimal EI thresholds for detecting patients with mean PAP ≥40 mmHg with C-statistics of 0.90 and patients with RVEF <40 % with C-statistics of 0.78. Systolic EIs were significantly greater for patients with LGE (1.45 ± 0.05) than for those without LGE (1.15 ± 0.07; p < 0.001). Conclusions:: EI offers a simple, comprehensive index that can predict pulmonary hypertension and RV dysfunction in CHD. Key points:: • EI offers a simple and comprehensive index of RV hemodynamics. • EI could predict pulmonary hypertension and RV dysfunction. • Left ventricular deformation expressed as high EI is related to myocardial fibrosis.

Original languageEnglish
Pages (from-to)3617-3625
Number of pages9
JournalEuropean Radiology
Volume26
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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