Clinical Impact of Preoperative Sarcopenia on the Postoperative Outcomes After Pancreas Transplantation

Yasunari Fukuda, Tadafumi Asaoka, Hidetoshi Eguchi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Toshinori Ito, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The importance of evaluating sarcopenia is increasingly being recognized in the field of transplantation because sarcopenia can have an adverse effect on the treatment outcomes. However, the clinical significance of preoperative sarcopenia on the postoperative outcomes following pancreas transplantation (PTx) has been largely unknown. The objective of this study was to investigate the role of preoperative sarcopenia in predicting the postoperative outcomes following PTx in recipients with type 1 diabetes mellitus (T1D). Methods: Forty-one recipients with severe T1D who underwent PTx were retrospectively reviewed. The psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC), as determined by preoperative computed tomography, were substituted for the quantity and quality of skeletal muscle for the definition of sarcopenia, respectively. Gender-specific quartiles were generated, and PMI lower than the first quantile or IMAC higher than the third quantile was considered to represent sarcopenia. The postoperative outcomes included postoperative surgical complications and pancreas graft survival. Results: Sarcopenia was identified in 11 recipients according to both the PMI and IMAC stratifications. The multivariate analyses revealed that high IMAC was independently associated with the development of postoperative surgical complications (odds ratio, 9.35; p = 0.016). In addition, the recipients with high IMAC showed unfavorable graft survival compared to those with normal IMAC (log-rank test; p = 0.038). In contrast, low PMI was not significantly associated with the postoperative outcomes. Conclusions: Our data suggested that preoperative sarcopenia, especially a decline in the quality of skeletal muscle, predicted poorer postoperative outcomes in T1D recipients undergoing PTx.

Original languageEnglish
Pages (from-to)3364-3371
Number of pages8
JournalWorld journal of surgery
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 1 2018
Externally publishedYes

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Sarcopenia
Pancreas Transplantation
Psoas Muscles
Adipose Tissue
Type 1 Diabetes Mellitus
Graft Survival
Skeletal Muscle
Pancreas
Multivariate Analysis
Transplantation
Odds Ratio
Tomography

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Fukuda, Y., Asaoka, T., Eguchi, H., Sasaki, K., Iwagami, Y., Yamada, D., ... Doki, Y. (2018). Clinical Impact of Preoperative Sarcopenia on the Postoperative Outcomes After Pancreas Transplantation. World journal of surgery, 42(10), 3364-3371. https://doi.org/10.1007/s00268-018-4639-1

Clinical Impact of Preoperative Sarcopenia on the Postoperative Outcomes After Pancreas Transplantation. / Fukuda, Yasunari; Asaoka, Tadafumi; Eguchi, Hidetoshi; Sasaki, Kazuki; Iwagami, Yoshifumi; Yamada, Daisaku; Noda, Takehiro; Kawamoto, Koichi; Gotoh, Kunihito; Kobayashi, Shogo; Ito, Toshinori; Takeda, Yutaka; Tanemura, Masahiro; Mori, Masaki; Doki, Yuichiro.

In: World journal of surgery, Vol. 42, No. 10, 01.10.2018, p. 3364-3371.

Research output: Contribution to journalArticle

Fukuda, Y, Asaoka, T, Eguchi, H, Sasaki, K, Iwagami, Y, Yamada, D, Noda, T, Kawamoto, K, Gotoh, K, Kobayashi, S, Ito, T, Takeda, Y, Tanemura, M, Mori, M & Doki, Y 2018, 'Clinical Impact of Preoperative Sarcopenia on the Postoperative Outcomes After Pancreas Transplantation', World journal of surgery, vol. 42, no. 10, pp. 3364-3371. https://doi.org/10.1007/s00268-018-4639-1
Fukuda, Yasunari ; Asaoka, Tadafumi ; Eguchi, Hidetoshi ; Sasaki, Kazuki ; Iwagami, Yoshifumi ; Yamada, Daisaku ; Noda, Takehiro ; Kawamoto, Koichi ; Gotoh, Kunihito ; Kobayashi, Shogo ; Ito, Toshinori ; Takeda, Yutaka ; Tanemura, Masahiro ; Mori, Masaki ; Doki, Yuichiro. / Clinical Impact of Preoperative Sarcopenia on the Postoperative Outcomes After Pancreas Transplantation. In: World journal of surgery. 2018 ; Vol. 42, No. 10. pp. 3364-3371.
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AU - Fukuda, Yasunari

AU - Asaoka, Tadafumi

AU - Eguchi, Hidetoshi

AU - Sasaki, Kazuki

AU - Iwagami, Yoshifumi

AU - Yamada, Daisaku

AU - Noda, Takehiro

AU - Kawamoto, Koichi

AU - Gotoh, Kunihito

AU - Kobayashi, Shogo

AU - Ito, Toshinori

AU - Takeda, Yutaka

AU - Tanemura, Masahiro

AU - Mori, Masaki

AU - Doki, Yuichiro

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N2 - Background: The importance of evaluating sarcopenia is increasingly being recognized in the field of transplantation because sarcopenia can have an adverse effect on the treatment outcomes. However, the clinical significance of preoperative sarcopenia on the postoperative outcomes following pancreas transplantation (PTx) has been largely unknown. The objective of this study was to investigate the role of preoperative sarcopenia in predicting the postoperative outcomes following PTx in recipients with type 1 diabetes mellitus (T1D). Methods: Forty-one recipients with severe T1D who underwent PTx were retrospectively reviewed. The psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC), as determined by preoperative computed tomography, were substituted for the quantity and quality of skeletal muscle for the definition of sarcopenia, respectively. Gender-specific quartiles were generated, and PMI lower than the first quantile or IMAC higher than the third quantile was considered to represent sarcopenia. The postoperative outcomes included postoperative surgical complications and pancreas graft survival. Results: Sarcopenia was identified in 11 recipients according to both the PMI and IMAC stratifications. The multivariate analyses revealed that high IMAC was independently associated with the development of postoperative surgical complications (odds ratio, 9.35; p = 0.016). In addition, the recipients with high IMAC showed unfavorable graft survival compared to those with normal IMAC (log-rank test; p = 0.038). In contrast, low PMI was not significantly associated with the postoperative outcomes. Conclusions: Our data suggested that preoperative sarcopenia, especially a decline in the quality of skeletal muscle, predicted poorer postoperative outcomes in T1D recipients undergoing PTx.

AB - Background: The importance of evaluating sarcopenia is increasingly being recognized in the field of transplantation because sarcopenia can have an adverse effect on the treatment outcomes. However, the clinical significance of preoperative sarcopenia on the postoperative outcomes following pancreas transplantation (PTx) has been largely unknown. The objective of this study was to investigate the role of preoperative sarcopenia in predicting the postoperative outcomes following PTx in recipients with type 1 diabetes mellitus (T1D). Methods: Forty-one recipients with severe T1D who underwent PTx were retrospectively reviewed. The psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC), as determined by preoperative computed tomography, were substituted for the quantity and quality of skeletal muscle for the definition of sarcopenia, respectively. Gender-specific quartiles were generated, and PMI lower than the first quantile or IMAC higher than the third quantile was considered to represent sarcopenia. The postoperative outcomes included postoperative surgical complications and pancreas graft survival. Results: Sarcopenia was identified in 11 recipients according to both the PMI and IMAC stratifications. The multivariate analyses revealed that high IMAC was independently associated with the development of postoperative surgical complications (odds ratio, 9.35; p = 0.016). In addition, the recipients with high IMAC showed unfavorable graft survival compared to those with normal IMAC (log-rank test; p = 0.038). In contrast, low PMI was not significantly associated with the postoperative outcomes. Conclusions: Our data suggested that preoperative sarcopenia, especially a decline in the quality of skeletal muscle, predicted poorer postoperative outcomes in T1D recipients undergoing PTx.

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