Clinical importance of endothelial function in arteriosclerosis and ischemic heart disease

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The vascular endothelium is a dynamic endocrine organ that regulates vascular tone, local homeostasis, and the fibro-inflammatory-proliferative process. These responses are mediated by various substances released from the endothelium in response to physiologic stimuli, including prostacyclin, endothelin and, most importantly, nitric oxide (NO). NO mediates vasodilation and inhibits platelet aggregation, thrombus formation, expression of adhesion molecules and chemokines for leukocytes, and oxidative stress. It also attenuates growth and proliferation of vascular smooth muscle cells. Risk factors for atherosclerosis, such as hypercholesterolemia, hypertension, diabetes and cigarette smoking, impair endothelial function, which leads to atherosclerosis and results in ischemic manifestations such as acute coronary syndrome and stroke. Thus, therapeutic intervention aimed at increasing NO bioavailability by statins or angiotensin-converting enzyme inhibitors might improve patient prognosis. Vascular endothelial function is an important and clinically relevant therapeutic target for cardiovascular disease.

Original languageEnglish
Pages (from-to)529-533
Number of pages5
JournalCirculation Journal
Volume66
Issue number6
DOIs
Publication statusPublished - Jan 1 2002

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Arteriosclerosis
Myocardial Ischemia
Nitric Oxide
Blood Vessels
Atherosclerosis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Endothelins
Vascular Endothelium
Cell Adhesion Molecules
Epoprostenol
Acute Coronary Syndrome
Hypercholesterolemia
Platelet Aggregation
Vascular Smooth Muscle
Chemokines
Angiotensin-Converting Enzyme Inhibitors
Vasodilation
Biological Availability
Smooth Muscle Myocytes
Endothelium

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Clinical importance of endothelial function in arteriosclerosis and ischemic heart disease. / Egashira, Kensuke.

In: Circulation Journal, Vol. 66, No. 6, 01.01.2002, p. 529-533.

Research output: Contribution to journalArticle

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