Abstract
Background The clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer remains incompletely understood. Methods Peritoneal washing samples were collected from 411 consecutive patients with pancreatic ductal adenocarcinoma from 1996 to 2014. Of the 411 patients, 335 underwent macroscopically curative resection and 76 with noncurative factors did not undergo resection. We compared long-term outcomes between patients with positive cytology (cytology+) and those with negative cytology (cytology−) and investigated the importance of clinicopathologic factors. Results Of 335 patients with curative resection, 300 (89.6%) were cytology− and 35 (10.4%) were cytology+. The median overall survival of cytology+ patients was less than that of cytology− patients (16 vs 31 months, respectively; P < .0001). The median overall survival of cytology+ patients with noncurative factors was significantly worse than that of cytology+ patients with curative resection (6.9 vs 16.0 months, respectively; P = .0023). The median disease-free survival of cytology+ patients was less than that of cytology− patients (6.5 vs 16 months, respectively; P < .0001). In the multivariate analysis, cytology+ was an independent prognostic factor for overall survival and disease-free survival. Conclusion Cytology+ without noncurative factors was a predictive factor for a poor prognosis. Therefore, it is important to regard patients with pancreatic cancer characterized by cytology+ as a special group that may warrant more aggressive adjuvant therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 951-958 |
| Number of pages | 8 |
| Journal | Surgery (United States) |
| Volume | 161 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2017 |
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All Science Journal Classification (ASJC) codes
- Surgery
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Clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer. / Abe, Toshiya; Ohuchida, Kenoki; Endo, Sho; Ookubo, Fumihiko; Mori, Yasuhisa; Nakata, Kohei; Miyasaka, Yoshihiro; Manabe, Tatsuya; Ohtsuka, Takao; Nagai, Eishi; Oda, Yoshinao; Nakamura, Masafumi.
In: Surgery (United States), Vol. 161, No. 4, 01.04.2017, p. 951-958.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer
AU - Abe, Toshiya
AU - Ohuchida, Kenoki
AU - Endo, Sho
AU - Ookubo, Fumihiko
AU - Mori, Yasuhisa
AU - Nakata, Kohei
AU - Miyasaka, Yoshihiro
AU - Manabe, Tatsuya
AU - Ohtsuka, Takao
AU - Nagai, Eishi
AU - Oda, Yoshinao
AU - Nakamura, Masafumi
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background The clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer remains incompletely understood. Methods Peritoneal washing samples were collected from 411 consecutive patients with pancreatic ductal adenocarcinoma from 1996 to 2014. Of the 411 patients, 335 underwent macroscopically curative resection and 76 with noncurative factors did not undergo resection. We compared long-term outcomes between patients with positive cytology (cytology+) and those with negative cytology (cytology−) and investigated the importance of clinicopathologic factors. Results Of 335 patients with curative resection, 300 (89.6%) were cytology− and 35 (10.4%) were cytology+. The median overall survival of cytology+ patients was less than that of cytology− patients (16 vs 31 months, respectively; P < .0001). The median overall survival of cytology+ patients with noncurative factors was significantly worse than that of cytology+ patients with curative resection (6.9 vs 16.0 months, respectively; P = .0023). The median disease-free survival of cytology+ patients was less than that of cytology− patients (6.5 vs 16 months, respectively; P < .0001). In the multivariate analysis, cytology+ was an independent prognostic factor for overall survival and disease-free survival. Conclusion Cytology+ without noncurative factors was a predictive factor for a poor prognosis. Therefore, it is important to regard patients with pancreatic cancer characterized by cytology+ as a special group that may warrant more aggressive adjuvant therapy.
AB - Background The clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer remains incompletely understood. Methods Peritoneal washing samples were collected from 411 consecutive patients with pancreatic ductal adenocarcinoma from 1996 to 2014. Of the 411 patients, 335 underwent macroscopically curative resection and 76 with noncurative factors did not undergo resection. We compared long-term outcomes between patients with positive cytology (cytology+) and those with negative cytology (cytology−) and investigated the importance of clinicopathologic factors. Results Of 335 patients with curative resection, 300 (89.6%) were cytology− and 35 (10.4%) were cytology+. The median overall survival of cytology+ patients was less than that of cytology− patients (16 vs 31 months, respectively; P < .0001). The median overall survival of cytology+ patients with noncurative factors was significantly worse than that of cytology+ patients with curative resection (6.9 vs 16.0 months, respectively; P = .0023). The median disease-free survival of cytology+ patients was less than that of cytology− patients (6.5 vs 16 months, respectively; P < .0001). In the multivariate analysis, cytology+ was an independent prognostic factor for overall survival and disease-free survival. Conclusion Cytology+ without noncurative factors was a predictive factor for a poor prognosis. Therefore, it is important to regard patients with pancreatic cancer characterized by cytology+ as a special group that may warrant more aggressive adjuvant therapy.
UR - http://www.scopus.com/inward/record.url?scp=85007565790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007565790&partnerID=8YFLogxK
U2 - 10.1016/j.surg.2016.10.035
DO - 10.1016/j.surg.2016.10.035
M3 - Article
C2 - 27939334
AN - SCOPUS:85007565790
VL - 161
SP - 951
EP - 958
JO - Surgery
JF - Surgery
SN - 0039-6060
IS - 4
ER -