Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus

Y. Ishii, K. Nagasawa, T. Mayumi, Y. Niho

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The clinical importance of IgG anticardiolipin antibodies was investigated in systemic lupus erythematosus (SLE). IgG anticardiolipin antibodies were found in 69 of 155 (44-5%) patients with SLE. Serial measurements of IgG anticardiolipin antibodies allowed the patients to be classified into two groups: group A, persistently positive for IgG anticardiolipin antibodies; group B, positive only in active phases. The IgG anticardiolipin antibody litre in group A was significantly higher than in group B. The incidence of thromboses, spontaneous abortions, and lupus anticoagulant in group A was significantly higher than in group B (p < 0-05). By contrast, the incidence of renal diseases and anti-dsDNA antibodies in group B was significantly higher than in group A (p < 0-05). This study showed that group A formed a separate subgroup of patients with SLE who had a high risk of thromboses and spontaneous abortions despite having milder disease activity.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume49
Issue number6
DOIs
Publication statusPublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Ophthalmology
  • Sensory Systems
  • Immunology
  • Rheumatology

Fingerprint Dive into the research topics of 'Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus'. Together they form a unique fingerprint.

  • Cite this