Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus

Y. Ishii, K. Nagasawa, T. Mayumi, Y. Niho

Research output: Contribution to journalArticle

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Abstract

The clinical importance of IgG anticardiolipin antibodies was investigated in systemic lupus erythematosus (SLE). IgG anticardiolipin antibodies were found in 69 of 155 (44-5%) patients with SLE. Serial measurements of IgG anticardiolipin antibodies allowed the patients to be classified into two groups: group A, persistently positive for IgG anticardiolipin antibodies; group B, positive only in active phases. The IgG anticardiolipin antibody litre in group A was significantly higher than in group B. The incidence of thromboses, spontaneous abortions, and lupus anticoagulant in group A was significantly higher than in group B (p < 0-05). By contrast, the incidence of renal diseases and anti-dsDNA antibodies in group B was significantly higher than in group A (p < 0-05). This study showed that group A formed a separate subgroup of patients with SLE who had a high risk of thromboses and spontaneous abortions despite having milder disease activity.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume49
Issue number6
DOIs
Publication statusPublished - 1990
Externally publishedYes

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Anticardiolipin Antibodies
Systemic Lupus Erythematosus
Immunoglobulin G
Spontaneous Abortion
Thrombosis
Lupus Coagulation Inhibitor
Incidence
Anti-Idiotypic Antibodies
Kidney
Antibodies

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Ophthalmology
  • Sensory Systems
  • Immunology
  • Rheumatology

Cite this

Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus. / Ishii, Y.; Nagasawa, K.; Mayumi, T.; Niho, Y.

In: Annals of the Rheumatic Diseases, Vol. 49, No. 6, 1990, p. 387-390.

Research output: Contribution to journalArticle

Ishii, Y. ; Nagasawa, K. ; Mayumi, T. ; Niho, Y. / Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus. In: Annals of the Rheumatic Diseases. 1990 ; Vol. 49, No. 6. pp. 387-390.
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