Clinical Outcome of Esophagectomy in Elderly Patients With and Without Neoadjuvant Therapy for Thoracic Esophageal Cancer

Hiroshi Miyata, Makoto Yamasaki, Tomoki Makino, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Esophageal cancer occurs predominantly in elderly people. To date, there is no standardized treatment protocol for elderly patients with esophageal cancer. The aim of the present study was to assess the effect of old age (≥80 years) on treatment and outcome of esophageal cancer. Methods: We divided 722 patients who underwent esophagectomy between January 2000 and December 2012 into 4 age groups (<70, ≥70 to <75, ≥75 to <80, and ≥80 years) and analyzed the differences among the groups in treatment strategy (preoperative treatment and surgery) and short- and long-term outcome after esophagectomy. Results: Preoperative chemotherapy was significantly less frequently used for the octogenarians than the other groups. Three-field lymphadenectomy was less frequently used with increasing age. Advanced age tended to be associated with higher frequency of postoperative pulmonary and cardiovascular complications, but not with change in mortality rate, compared with younger patients. The overall survival rate was significantly lower in patients of the group≥75 to <80 and group≥80, compared with group<70 (p = 0.011, p = 0.002). Advanced age, low body mass index, postoperative complications, and pathological stage were independent and significant prognostic factors in elderly patients who underwent esophagectomy. Conclusions: Elderly patients aged 75 years and more, especially octogenarians, showed relatively poor prognosis compared with younger patients partly because they less often received neoadjuvant therapy. Aggressive treatment may be recommended for elderly patients after taking into careful consideration the overall physical condition.

Original languageEnglish
Pages (from-to)794-801
Number of pages8
JournalAnnals of Surgical Oncology
Volume22
DOIs
Publication statusPublished - Dec 1 2015
Externally publishedYes

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Neoadjuvant Therapy
Esophagectomy
Esophageal Neoplasms
Thorax
Clinical Protocols
Lymph Node Excision
Body Mass Index
Therapeutics
Survival Rate
Age Groups
Drug Therapy
Lung
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Clinical Outcome of Esophagectomy in Elderly Patients With and Without Neoadjuvant Therapy for Thoracic Esophageal Cancer. / Miyata, Hiroshi; Yamasaki, Makoto; Makino, Tomoki; Miyazaki, Yasuhiro; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro.

In: Annals of Surgical Oncology, Vol. 22, 01.12.2015, p. 794-801.

Research output: Contribution to journalArticle

Miyata, H, Yamasaki, M, Makino, T, Miyazaki, Y, Takahashi, T, Kurokawa, Y, Nakajima, K, Takiguchi, S, Mori, M & Doki, Y 2015, 'Clinical Outcome of Esophagectomy in Elderly Patients With and Without Neoadjuvant Therapy for Thoracic Esophageal Cancer', Annals of Surgical Oncology, vol. 22, pp. 794-801. https://doi.org/10.1245/s10434-015-4769-8
Miyata, Hiroshi ; Yamasaki, Makoto ; Makino, Tomoki ; Miyazaki, Yasuhiro ; Takahashi, Tsuyoshi ; Kurokawa, Yukinori ; Nakajima, Kiyokazu ; Takiguchi, Shuji ; Mori, Masaki ; Doki, Yuichiro. / Clinical Outcome of Esophagectomy in Elderly Patients With and Without Neoadjuvant Therapy for Thoracic Esophageal Cancer. In: Annals of Surgical Oncology. 2015 ; Vol. 22. pp. 794-801.
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AU - Takahashi, Tsuyoshi

AU - Kurokawa, Yukinori

AU - Nakajima, Kiyokazu

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