Clinical outcome of lower esophageal sphincter- and vagus-nerve-preserving partial cardiectomy for early gastric cancer of the subcardia

Hideo Matsumoto, Haruaki Murakami, Hisako Kubota, Masaharu Higashida, Masafumi Nakamura, Toshihiro Hirai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: No definitive operative method has been established for the treatment of early subcardial gastric cancer. Our newly developed technique involves local resection of the subcardia while preserving the lower esophageal sphincter and vagus nerve. A new fornix is constructed to accept the transposed esophagus. Methods: Thirty patients underwent this procedure between July 2003 and December 2010. Continuous gastric pH monitoring was performed immediately after surgery, and esophageal manometry was undertaken 1 month later. Serum total protein, albumin, total cholesterol, cholinesterase, and body mass index (BMI) were recorded every 3 months. Pre- and postoperative oral intake were compared, reflux symptoms were recorded, and reflux esophagitis was assessed by endoscopy after 1 year. Results: Twenty-five patients (86 %) reported no symptoms of reflux, and 27 (92.8 %) patients could eat 70 % or more of what they had eaten before surgery. Lower esophageal pressures were found to be >10 mmHg in 66.7 % of patients, and the fraction of time that pH <4 was <5 % of the 24-h monitoring period in 70 %. Serum parameters and BMI were unchanged. Conclusions: This surgical technique is a useful means of preserving postoperative quality of life after local gastrectomy by preventing reflux and maintaining nutritional status.

Original languageEnglish
Pages (from-to)669-674
Number of pages6
JournalGastric Cancer
Volume18
Issue number3
DOIs
Publication statusPublished - Jul 27 2015

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Lower Esophageal Sphincter
Vagus Nerve
Stomach Neoplasms
Body Mass Index
Peptic Esophagitis
Cholinesterases
Manometry
Gastrectomy
Nutritional Status
Esophagus
Endoscopy
Blood Proteins
Albumins
Stomach
Cholesterol
Quality of Life
Pressure
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Gastroenterology
  • Cancer Research

Cite this

Clinical outcome of lower esophageal sphincter- and vagus-nerve-preserving partial cardiectomy for early gastric cancer of the subcardia. / Matsumoto, Hideo; Murakami, Haruaki; Kubota, Hisako; Higashida, Masaharu; Nakamura, Masafumi; Hirai, Toshihiro.

In: Gastric Cancer, Vol. 18, No. 3, 27.07.2015, p. 669-674.

Research output: Contribution to journalArticle

Matsumoto, Hideo ; Murakami, Haruaki ; Kubota, Hisako ; Higashida, Masaharu ; Nakamura, Masafumi ; Hirai, Toshihiro. / Clinical outcome of lower esophageal sphincter- and vagus-nerve-preserving partial cardiectomy for early gastric cancer of the subcardia. In: Gastric Cancer. 2015 ; Vol. 18, No. 3. pp. 669-674.
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