Clinical practice recommendations for the diagnosis and management of human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation: the Japan Society for Hematopoietic Cell Transplantation

Masao Ogata, Naoyuki Uchida, Takahiro Fukuda, Kazuhiro Ikegame, Tomohiko Kamimura, Makoto Onizuka, Koji Kato, Hikaru Kobayashi, Yoji Sasahara, Masashi Sawa, Akihisa Sawada, Daiichiro Hasegawa, Masayoshi Masuko, Toshihiro Miyamoto, Shinichiro Okamoto

Research output: Contribution to journalReview article

Abstract

Reactivation of human herpesvirus (HHV)-6B is relatively common after allogeneic hematopoietic stem cell transplantation (HSCT) and HHV-6B diseases may consequently develop. Among them, HHV-6B encephalitis is a serious and often fatal complication. The aim of these clinical practice recommendations is to provide diagnostic and therapeutic guidance for HHV-6B encephalitis after allogeneic HSCT. In this evidence-based review, we critically evaluated data from the published literature. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to assist in generating recommendations. We have summarized the findings that contribute to decision-making and we have provided our recommendations. In cases where rigorous clinical data are unavailable, recommendations have been developed in discussions with physicians who have relevant expertize.

Original languageEnglish
JournalBone Marrow Transplantation
DOIs
Publication statusAccepted/In press - Jan 1 2019

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this