Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis

S. Furukawa, Masafumi Moriyama, Shintarou Kawano, A. Tanaka, takashi maehara, Hayashida Jun-Nosuke, Y. Goto, Tamotsu Kiyoshima, H. Shiratsuchi, Yukiko Ohyama, M. Ohta, Y. Imabayashi, Seiji Nakamura

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Abstract

Objectives: Küttner tumour (KT), so-called chronic sclerosing sialoadenitis, is characterised by concomitant swelling of the submandibular glands secondary to strong lymphocytic infiltration and fibrosis independent of sialolith formation. However, recent studies have indicated that some patients with KT develop high serum levels of IgG4 and infiltration of IgG4-positive plasma cells, namely IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease. The aim of this study was to clarify the clinical and pathological associations between KT and IgG4-DS. Materials and Methods: Fifty-four patients pathologically diagnosed with KT or chronic sialoadenitis were divided into two groups according to the presence or absence of sialolith (KT-S (+) or KT-S (-), respectively). Results: There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups. All patients in the KT-S (+) group showed unilateral swelling without infiltration of IgG4-positive plasma cells or a history of other IgG4-related diseases (IgG4-RD), while those in the KT-S (-) group showed bilateral swelling (37.5%), strong infiltration of IgG4-positive plasma cells (87.5%) and a history of other IgG4-RD (12.5%). Conclusions: These results suggest an association between the pathogeneses of KT-S (-) and IgG4-DS, but not KT-S (+).

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalOral Diseases
Volume21
Issue number2
DOIs
Publication statusPublished - Jan 1 2015

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Dacryocystitis
Sialadenitis
Immunoglobulin G
Neoplasms
Plasma Cells
Salivary Gland Calculi
Mikulicz' Disease
Submandibular Gland
Fibrosis

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis. / Furukawa, S.; Moriyama, Masafumi; Kawano, Shintarou; Tanaka, A.; maehara, takashi; Jun-Nosuke, Hayashida; Goto, Y.; Kiyoshima, Tamotsu; Shiratsuchi, H.; Ohyama, Yukiko; Ohta, M.; Imabayashi, Y.; Nakamura, Seiji.

In: Oral Diseases, Vol. 21, No. 2, 01.01.2015, p. 257-262.

Research output: Contribution to journalArticle

Furukawa, S. ; Moriyama, Masafumi ; Kawano, Shintarou ; Tanaka, A. ; maehara, takashi ; Jun-Nosuke, Hayashida ; Goto, Y. ; Kiyoshima, Tamotsu ; Shiratsuchi, H. ; Ohyama, Yukiko ; Ohta, M. ; Imabayashi, Y. ; Nakamura, Seiji. / Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis. In: Oral Diseases. 2015 ; Vol. 21, No. 2. pp. 257-262.
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T1 - Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis

AU - Furukawa, S.

AU - Moriyama, Masafumi

AU - Kawano, Shintarou

AU - Tanaka, A.

AU - maehara, takashi

AU - Jun-Nosuke, Hayashida

AU - Goto, Y.

AU - Kiyoshima, Tamotsu

AU - Shiratsuchi, H.

AU - Ohyama, Yukiko

AU - Ohta, M.

AU - Imabayashi, Y.

AU - Nakamura, Seiji

PY - 2015/1/1

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N2 - Objectives: Küttner tumour (KT), so-called chronic sclerosing sialoadenitis, is characterised by concomitant swelling of the submandibular glands secondary to strong lymphocytic infiltration and fibrosis independent of sialolith formation. However, recent studies have indicated that some patients with KT develop high serum levels of IgG4 and infiltration of IgG4-positive plasma cells, namely IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease. The aim of this study was to clarify the clinical and pathological associations between KT and IgG4-DS. Materials and Methods: Fifty-four patients pathologically diagnosed with KT or chronic sialoadenitis were divided into two groups according to the presence or absence of sialolith (KT-S (+) or KT-S (-), respectively). Results: There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups. All patients in the KT-S (+) group showed unilateral swelling without infiltration of IgG4-positive plasma cells or a history of other IgG4-related diseases (IgG4-RD), while those in the KT-S (-) group showed bilateral swelling (37.5%), strong infiltration of IgG4-positive plasma cells (87.5%) and a history of other IgG4-RD (12.5%). Conclusions: These results suggest an association between the pathogeneses of KT-S (-) and IgG4-DS, but not KT-S (+).

AB - Objectives: Küttner tumour (KT), so-called chronic sclerosing sialoadenitis, is characterised by concomitant swelling of the submandibular glands secondary to strong lymphocytic infiltration and fibrosis independent of sialolith formation. However, recent studies have indicated that some patients with KT develop high serum levels of IgG4 and infiltration of IgG4-positive plasma cells, namely IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease. The aim of this study was to clarify the clinical and pathological associations between KT and IgG4-DS. Materials and Methods: Fifty-four patients pathologically diagnosed with KT or chronic sialoadenitis were divided into two groups according to the presence or absence of sialolith (KT-S (+) or KT-S (-), respectively). Results: There were no significant differences in the clinical findings, including the mean age, sex and disease duration, between the two groups. All patients in the KT-S (+) group showed unilateral swelling without infiltration of IgG4-positive plasma cells or a history of other IgG4-related diseases (IgG4-RD), while those in the KT-S (-) group showed bilateral swelling (37.5%), strong infiltration of IgG4-positive plasma cells (87.5%) and a history of other IgG4-RD (12.5%). Conclusions: These results suggest an association between the pathogeneses of KT-S (-) and IgG4-DS, but not KT-S (+).

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