Clinical results of radiation therapy for stage I esophageal cancer: A single institutional experience

Yoshiyuki Shioyama, Katsumasa Nakamura, Tomonari Sasaki, Saiji Ooga, Yusuke Urashima, Masahiko Kimura, Satoru Uehara, Hiromi Terashima, Hiroshi Honda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

From 1992 through 2001, 29 patients with stage I esophageal cancer were treated with radiation therapy. All patients had squamous cell carcinoma. Seventeen patients were treated with radiotherapy alone, and 12 were treated with a combination of chemotherapy and radiotherapy. Most of the chemotherapy regimens included cisplatin and/or 5-fluorouracil (5-FU). Twelve patients were treated with intracavitary irradiation (low-dose rate: 6, high-dose rate: 6) after external radiotherapy. Median fraction and total doses of external radiotherapy given were 2.0 Gy and 60.6 Gy, respectively. Median doses of intracavitary irradiation were 18 Gy/6 fractions in low-dose-rate brachytherapy and 13.5 Gy/4.5 fractions in high-dose-rate brachytherapy. The 5-year overall survival rate was 62%. The 5-year local control rate was 44%. Of the 29 patients, 9 had in-field recurrence in the esophagus and 1 had recurrence in the esophagus outside of the irradiated field. Of 9 patients with in-field local recurrence, 1 also developed mediastinal lymph node metastases and 1 had distant metastasis. Radiation therapy is an effective treatment modality for stage I esophageal cancer.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume28
Issue number1
DOIs
Publication statusPublished - Feb 1 2005

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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