Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients

Tetsuya Ikemoto, Takeshi Yamaguchi, Yuji Morine, Satoru Imura, Yuji Soejima, Masahiko Fujii, Yoichi Maekawa, Koji Yasutomo, Mitsuo Shimada

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

OBJECTIVES: Further metastasis should be avoided in pancreatic cancer (PC) patients for effective surgical treatment. Regulatory T cells (Foxp3CD4 T cells including CD4CD25 T cells and CD4CD25 T cells) play important roles in tumor immunity. This study aimed to investigate whether regulatory T cells participate in metastasis. METHODS: Peripheral blood was withdrawn from PC patients, as well as healthy volunteer donors as controls. The peripheral blood mononuclear cells (PBMCs) were subjected to FACScan analysis after labeling with anti-CD4, anti-CD25, and anti-Foxp3 antibodies. Tumor markers, including DUPAN2 and CA19-9, surface markers, such as the CD4/CD8 ratio, and the CD57 cell population were assessed. Clinical stages were classified according to the TNM classification. RESULTS: The Foxp3CD4 T-cell population among the PBMCs was significantly increased in PC patients (8.10% ± 4.65%) compared with healthy donors (2.47 ± 0.78%) (P < 0.001). No significant relationships existed for the tumor markers, CD4/CD8 ratio, and CD57 cells. However, a significant correlation was found between Foxp3CD4 T cells among the PBMCs and the TNM stage (P < 0.05). CONCLUSIONS: Foxp3CD4 T cells are good markers for metastasis detection in PC patients and more accurate than other conventional tumor markers, especially at advanced stages of the disease.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalPancreas
Volume33
Issue number4
DOIs
Publication statusPublished - Nov 1 2006
Externally publishedYes

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Pancreatic Neoplasms
T-Lymphocytes
Tumor Biomarkers
Population
Blood Cells
CD4-CD8 Ratio
Regulatory T-Lymphocytes
Neoplasm Metastasis
Tissue Donors
Neoplasm Staging
Anti-Idiotypic Antibodies
Immunity
Healthy Volunteers
Neoplasms

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients. / Ikemoto, Tetsuya; Yamaguchi, Takeshi; Morine, Yuji; Imura, Satoru; Soejima, Yuji; Fujii, Masahiko; Maekawa, Yoichi; Yasutomo, Koji; Shimada, Mitsuo.

In: Pancreas, Vol. 33, No. 4, 01.11.2006, p. 386-390.

Research output: Contribution to journalArticle

Ikemoto, T, Yamaguchi, T, Morine, Y, Imura, S, Soejima, Y, Fujii, M, Maekawa, Y, Yasutomo, K & Shimada, M 2006, 'Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients', Pancreas, vol. 33, no. 4, pp. 386-390. https://doi.org/10.1097/01.mpa.0000240275.68279.13
Ikemoto, Tetsuya ; Yamaguchi, Takeshi ; Morine, Yuji ; Imura, Satoru ; Soejima, Yuji ; Fujii, Masahiko ; Maekawa, Yoichi ; Yasutomo, Koji ; Shimada, Mitsuo. / Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients. In: Pancreas. 2006 ; Vol. 33, No. 4. pp. 386-390.
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AU - Soejima, Yuji

AU - Fujii, Masahiko

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AU - Yasutomo, Koji

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N2 - OBJECTIVES: Further metastasis should be avoided in pancreatic cancer (PC) patients for effective surgical treatment. Regulatory T cells (Foxp3CD4 T cells including CD4CD25 T cells and CD4CD25 T cells) play important roles in tumor immunity. This study aimed to investigate whether regulatory T cells participate in metastasis. METHODS: Peripheral blood was withdrawn from PC patients, as well as healthy volunteer donors as controls. The peripheral blood mononuclear cells (PBMCs) were subjected to FACScan analysis after labeling with anti-CD4, anti-CD25, and anti-Foxp3 antibodies. Tumor markers, including DUPAN2 and CA19-9, surface markers, such as the CD4/CD8 ratio, and the CD57 cell population were assessed. Clinical stages were classified according to the TNM classification. RESULTS: The Foxp3CD4 T-cell population among the PBMCs was significantly increased in PC patients (8.10% ± 4.65%) compared with healthy donors (2.47 ± 0.78%) (P < 0.001). No significant relationships existed for the tumor markers, CD4/CD8 ratio, and CD57 cells. However, a significant correlation was found between Foxp3CD4 T cells among the PBMCs and the TNM stage (P < 0.05). CONCLUSIONS: Foxp3CD4 T cells are good markers for metastasis detection in PC patients and more accurate than other conventional tumor markers, especially at advanced stages of the disease.

AB - OBJECTIVES: Further metastasis should be avoided in pancreatic cancer (PC) patients for effective surgical treatment. Regulatory T cells (Foxp3CD4 T cells including CD4CD25 T cells and CD4CD25 T cells) play important roles in tumor immunity. This study aimed to investigate whether regulatory T cells participate in metastasis. METHODS: Peripheral blood was withdrawn from PC patients, as well as healthy volunteer donors as controls. The peripheral blood mononuclear cells (PBMCs) were subjected to FACScan analysis after labeling with anti-CD4, anti-CD25, and anti-Foxp3 antibodies. Tumor markers, including DUPAN2 and CA19-9, surface markers, such as the CD4/CD8 ratio, and the CD57 cell population were assessed. Clinical stages were classified according to the TNM classification. RESULTS: The Foxp3CD4 T-cell population among the PBMCs was significantly increased in PC patients (8.10% ± 4.65%) compared with healthy donors (2.47 ± 0.78%) (P < 0.001). No significant relationships existed for the tumor markers, CD4/CD8 ratio, and CD57 cells. However, a significant correlation was found between Foxp3CD4 T cells among the PBMCs and the TNM stage (P < 0.05). CONCLUSIONS: Foxp3CD4 T cells are good markers for metastasis detection in PC patients and more accurate than other conventional tumor markers, especially at advanced stages of the disease.

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