Clinical safety of brain magnetic resonance imaging with implanted deep brain stimulation hardware: Large case series and review of the literature

Ludvic Zrinzo, Fumiaki Yoshida, Marwan I. Hariz, John Thornton, Thomas Foltynie, Tarek A. Yousry, Patricia Limousin

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Background: Over 75,000 patients have undergone deep brain stimulation (DBS) procedures worldwide. Magnetic resonance imaging (MRI) is an important clinical and research tool in analyzing electrode location, documenting postoperative complications, and investigating novel symptoms in DBS patients. Functional MRI may shed light on the mechanism of action of DBS. MRI safety in DBS patients is therefore an important consideration. Methods: We report our experience with MRI in patients with implanted DBS hardware and examine the literature for clinical reports on MRI safety with implanted DBS hardware. Results: A total of 262 MRI examinations were performed in 223 patients with intracranial DBS hardware, including 45 in patients with an implanted pulse generator. Only 1 temporary adverse event occurred related to patient agitation and movement during immediate postoperative MR imaging. Agitation resolved after a few hours, and an MRI obtained before implanted pulse generator implantation revealed edema around both electrodes. Over 4000 MRI examinations in patients with implanted DBS hardware have been reported in the literature. Only 4 led to adverse events, including 2 hardware failures, 1 temporary and 1 permanent neurological deficit. Adverse neurological events occurred in a unique set of circumstances where appropriate safety protocols were not followed. MRI guidelines provided by DBS hardware manufacturers are inconsistent and vary among devices. Conclusions: The importance of MRI in modern medicine places pressure on industry to develop fully MRI-compatible DBS devices. Until then, the literature suggests that, when observing certain precautions, cranial MR images can be obtained with an extremely low risk in patients with implanted DBS hardware.

Original languageEnglish
Pages (from-to)164-172
Number of pages9
JournalWorld Neurosurgery
Volume76
Issue number1-2
DOIs
Publication statusPublished - Jul 1 2011

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Deep Brain Stimulation
Magnetic Resonance Imaging
Safety
Brain
Electrodes
Equipment and Supplies
Modern 1601-history
Edema
Industry
Guidelines

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Clinical safety of brain magnetic resonance imaging with implanted deep brain stimulation hardware : Large case series and review of the literature. / Zrinzo, Ludvic; Yoshida, Fumiaki; Hariz, Marwan I.; Thornton, John; Foltynie, Thomas; Yousry, Tarek A.; Limousin, Patricia.

In: World Neurosurgery, Vol. 76, No. 1-2, 01.07.2011, p. 164-172.

Research output: Contribution to journalReview article

Zrinzo, Ludvic ; Yoshida, Fumiaki ; Hariz, Marwan I. ; Thornton, John ; Foltynie, Thomas ; Yousry, Tarek A. ; Limousin, Patricia. / Clinical safety of brain magnetic resonance imaging with implanted deep brain stimulation hardware : Large case series and review of the literature. In: World Neurosurgery. 2011 ; Vol. 76, No. 1-2. pp. 164-172.
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