Clinical Significance of Fronto-Temporal Gray Matter Atrophy in Executive Dysfunction in Patients with Chronic Kidney Disease: The VCOHP Study

Kazuhiko Tsuruya, Hisako Yoshida, Naoki Haruyama, Kiichiro Fujisaki, Hideki Hirakata, Takanari Kitazono

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background & Objectives It is well known that cognitive impairment in patients with chronic kidney disease (CKD) is characterized by executive dysfunction, rather than memory dysfunction, although the precise mechanism of this remains to be elucidated. The purpose of the present study is to examine the correlation between gray matter volume (GMV) and executive function in CKD patients. Design, Setting, Participants, Measurements This cross-sectional study recruited 95 patients with non-dialysis-dependent CKD (NDDCKD) with no history of cerebrovascular disease, who underwent brain magnetic resonance imaging (MRI) and Trail Making Test (TMT) in the VCOHP Study. The subjects underwent brain MRI and TMT part A (TMT-A) and part B (TMT-B). The segmentation algorithm from Statistical Parametric Mapping 8 software was applied to every T1-weighted MRI scan to extract tissue maps corresponding to gray matter, white matter, and cerebrospinal fluid. GMV was normalized by dividing by the total intracranial volume, calculated by adding GMV, white matter volume, and cerebrospinal fluid space volume. Then, normalized wholebrain GMV was divided into four categories of brain lobes; frontal, parietal, temporal, and occipital. We assessed the correlation between normalized GMV and TMT using multivariable regression analysis. Results Normalized whole-brain GMV was significantly inversely correlated to the scores of TMT-A, TMT-B, and ΔTMT (TMT-B minus TMT-A). These correlations remained significant even after adjusting for relevant confounding factors. Normalized frontal and temporal GMV, but not parietal and occipital GMV, were significantly inversely correlated with TMT-A, TMT-B, and ΔTMT using multivariable regression analysis. Conclusions The present study demonstrates the correlation between normalized GMV, especially in the frontal and temporal lobes, and executive function, suggesting that fronto-temporal gray matter atrophy might contribute to executive dysfunction in NDD-CKD.

Original languageEnglish
Article numbere0143706
JournalPloS one
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

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Trail Making Test
kidney diseases
atrophy
Chronic Renal Insufficiency
Atrophy
Brain
Magnetic resonance
Cerebrospinal fluid
Imaging techniques
Regression analysis
testing
magnetic resonance imaging
Tissue Extracts
brain
Executive Function
Magnetic Resonance Imaging
cerebrospinal fluid
Cerebrospinal Fluid
Gray Matter
regression analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Clinical Significance of Fronto-Temporal Gray Matter Atrophy in Executive Dysfunction in Patients with Chronic Kidney Disease : The VCOHP Study. / Tsuruya, Kazuhiko; Yoshida, Hisako; Haruyama, Naoki; Fujisaki, Kiichiro; Hirakata, Hideki; Kitazono, Takanari.

In: PloS one, Vol. 10, No. 12, e0143706, 01.12.2015.

Research output: Contribution to journalArticle

Tsuruya, Kazuhiko ; Yoshida, Hisako ; Haruyama, Naoki ; Fujisaki, Kiichiro ; Hirakata, Hideki ; Kitazono, Takanari. / Clinical Significance of Fronto-Temporal Gray Matter Atrophy in Executive Dysfunction in Patients with Chronic Kidney Disease : The VCOHP Study. In: PloS one. 2015 ; Vol. 10, No. 12.
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