Clinical significance of growth differentiation factor 11 in colorectal cancer

Takeshi Yokoe, Takahiro Ohmachi, Hiroshi Inoue, Koshi Mimori, Fumiaki Tanaka, Masato Kusunoki, Masaki Mori

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-ß superfamily and bone morphogenetic protein (BMP) subfamily, plays a role in regulation of development and differentiation. Although some members of BMP subfamily have been reported to correlate with cancer, the significance of GDF11 has not been studied in a clinical oncology setting. The current study explored the clinicopathological significance of GDF11 expression in colorectal cancer. Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001). Tumors were classified as high GDF11 expression (n=65) or low GDF11 expression (n=65). Patients whose tumors had high GDF11 expression showed a high frequency of lymph node metastasis (p=0.049) and had more cancer-related deaths (p=0.040). Furthermore, the patients with high GDF11 expression had significantly poorer overall survival than those with low expression (p=0.0334). Although multivariate analysis showed that GDF11 was not an independent prognostic factor, these findings suggest that GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer.

Original languageEnglish
Pages (from-to)1097-1101
Number of pages5
JournalInternational Journal of Oncology
Volume31
Issue number5
Publication statusPublished - Nov 1 2007

Fingerprint

Growth Differentiation Factors
Colorectal Neoplasms
Bone Morphogenetic Proteins
Neoplasms
Medical Oncology
Transforming Growth Factors
Reverse Transcription
Multivariate Analysis
Biomarkers
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yokoe, T., Ohmachi, T., Inoue, H., Mimori, K., Tanaka, F., Kusunoki, M., & Mori, M. (2007). Clinical significance of growth differentiation factor 11 in colorectal cancer. International Journal of Oncology, 31(5), 1097-1101.

Clinical significance of growth differentiation factor 11 in colorectal cancer. / Yokoe, Takeshi; Ohmachi, Takahiro; Inoue, Hiroshi; Mimori, Koshi; Tanaka, Fumiaki; Kusunoki, Masato; Mori, Masaki.

In: International Journal of Oncology, Vol. 31, No. 5, 01.11.2007, p. 1097-1101.

Research output: Contribution to journalArticle

Yokoe, T, Ohmachi, T, Inoue, H, Mimori, K, Tanaka, F, Kusunoki, M & Mori, M 2007, 'Clinical significance of growth differentiation factor 11 in colorectal cancer', International Journal of Oncology, vol. 31, no. 5, pp. 1097-1101.
Yokoe T, Ohmachi T, Inoue H, Mimori K, Tanaka F, Kusunoki M et al. Clinical significance of growth differentiation factor 11 in colorectal cancer. International Journal of Oncology. 2007 Nov 1;31(5):1097-1101.
Yokoe, Takeshi ; Ohmachi, Takahiro ; Inoue, Hiroshi ; Mimori, Koshi ; Tanaka, Fumiaki ; Kusunoki, Masato ; Mori, Masaki. / Clinical significance of growth differentiation factor 11 in colorectal cancer. In: International Journal of Oncology. 2007 ; Vol. 31, No. 5. pp. 1097-1101.
@article{d0445c252d874a398a5b07f591f75b3c,
title = "Clinical significance of growth differentiation factor 11 in colorectal cancer",
abstract = "Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-{\ss} superfamily and bone morphogenetic protein (BMP) subfamily, plays a role in regulation of development and differentiation. Although some members of BMP subfamily have been reported to correlate with cancer, the significance of GDF11 has not been studied in a clinical oncology setting. The current study explored the clinicopathological significance of GDF11 expression in colorectal cancer. Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001). Tumors were classified as high GDF11 expression (n=65) or low GDF11 expression (n=65). Patients whose tumors had high GDF11 expression showed a high frequency of lymph node metastasis (p=0.049) and had more cancer-related deaths (p=0.040). Furthermore, the patients with high GDF11 expression had significantly poorer overall survival than those with low expression (p=0.0334). Although multivariate analysis showed that GDF11 was not an independent prognostic factor, these findings suggest that GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer.",
author = "Takeshi Yokoe and Takahiro Ohmachi and Hiroshi Inoue and Koshi Mimori and Fumiaki Tanaka and Masato Kusunoki and Masaki Mori",
year = "2007",
month = "11",
day = "1",
language = "English",
volume = "31",
pages = "1097--1101",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "5",

}

TY - JOUR

T1 - Clinical significance of growth differentiation factor 11 in colorectal cancer

AU - Yokoe, Takeshi

AU - Ohmachi, Takahiro

AU - Inoue, Hiroshi

AU - Mimori, Koshi

AU - Tanaka, Fumiaki

AU - Kusunoki, Masato

AU - Mori, Masaki

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-ß superfamily and bone morphogenetic protein (BMP) subfamily, plays a role in regulation of development and differentiation. Although some members of BMP subfamily have been reported to correlate with cancer, the significance of GDF11 has not been studied in a clinical oncology setting. The current study explored the clinicopathological significance of GDF11 expression in colorectal cancer. Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001). Tumors were classified as high GDF11 expression (n=65) or low GDF11 expression (n=65). Patients whose tumors had high GDF11 expression showed a high frequency of lymph node metastasis (p=0.049) and had more cancer-related deaths (p=0.040). Furthermore, the patients with high GDF11 expression had significantly poorer overall survival than those with low expression (p=0.0334). Although multivariate analysis showed that GDF11 was not an independent prognostic factor, these findings suggest that GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer.

AB - Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-ß superfamily and bone morphogenetic protein (BMP) subfamily, plays a role in regulation of development and differentiation. Although some members of BMP subfamily have been reported to correlate with cancer, the significance of GDF11 has not been studied in a clinical oncology setting. The current study explored the clinicopathological significance of GDF11 expression in colorectal cancer. Quantitative real-time reverse transcription-PCR in colorectal cancer specimens obtained from 130 patients showed that GDF11 mRNA expression in cancer tissue was significantly higher than in normal tissue (p=0.001). Tumors were classified as high GDF11 expression (n=65) or low GDF11 expression (n=65). Patients whose tumors had high GDF11 expression showed a high frequency of lymph node metastasis (p=0.049) and had more cancer-related deaths (p=0.040). Furthermore, the patients with high GDF11 expression had significantly poorer overall survival than those with low expression (p=0.0334). Although multivariate analysis showed that GDF11 was not an independent prognostic factor, these findings suggest that GDF11 may be a novel diagnostic and prognostic biomarker in patients with colorectal cancer.

UR - http://www.scopus.com/inward/record.url?scp=38449120316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449120316&partnerID=8YFLogxK

M3 - Article

C2 - 17912435

AN - SCOPUS:38449120316

VL - 31

SP - 1097

EP - 1101

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 5

ER -