Integrin α6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin α6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumors. Concerning the variant, there was a significant correlation between the expression ratio of variant B/variant A and the depth of tumor invasion. In conclusion, i) integrin α6 expression was intimately correlated with histologic differentiation, and ii) the overexpression of variant B may be correlated with tumor invasion of gastric carcinoma.
|Number of pages||6|
|Journal||International journal of oncology|
|Publication status||Published - Jan 1 1997|
All Science Journal Classification (ASJC) codes
- Cancer Research