Clinical significance of integrin α6 mRNA expression in gastric carcinoma

Koshi Mimori; Masaki Mori; Nasim A. Begum; Shinji Tanaka; Masaru Haraguchi; Hiroaki Ueo; Nobuya Karimine; Tsuyoshi Akiyoshi; Graham F. Barnard

Clinical significance of integrin α6 mRNA expression in gastric carcinoma

Koshi Mimori, Masaki Mori, Nasim A. Begum, Shinji Tanaka, Masaru Haraguchi, Hiroaki Ueo, Nobuya Karimine, Tsuyoshi Akiyoshi, Graham F. Barnard

Research output: Contribution to journal › Article › peer-review

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Abstract

Integrin α6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin α6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumors. Concerning the variant, there was a significant correlation between the expression ratio of variant B/variant A and the depth of tumor invasion. In conclusion, i) integrin α6 expression was intimately correlated with histologic differentiation, and ii) the overexpression of variant B may be correlated with tumor invasion of gastric carcinoma.

Original language	English
Pages (from-to)	959-964
Number of pages	6
Journal	International journal of oncology
Volume	11
Issue number	5
Publication status	Published - Jan 1 1997

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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title = "Clinical significance of integrin α6 mRNA expression in gastric carcinoma",

abstract = "Integrin α6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin α6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumors. Concerning the variant, there was a significant correlation between the expression ratio of variant B/variant A and the depth of tumor invasion. In conclusion, i) integrin α6 expression was intimately correlated with histologic differentiation, and ii) the overexpression of variant B may be correlated with tumor invasion of gastric carcinoma.",

author = "Koshi Mimori and Masaki Mori and Begum, {Nasim A.} and Shinji Tanaka and Masaru Haraguchi and Hiroaki Ueo and Nobuya Karimine and Tsuyoshi Akiyoshi and Barnard, {Graham F.}",

year = "1997",

month = jan,

day = "1",

language = "English",

volume = "11",

pages = "959--964",

journal = "International Journal of Oncology",

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TY - JOUR

T1 - Clinical significance of integrin α6 mRNA expression in gastric carcinoma

AU - Mimori, Koshi

AU - Mori, Masaki

AU - Begum, Nasim A.

AU - Tanaka, Shinji

AU - Haraguchi, Masaru

AU - Ueo, Hiroaki

AU - Karimine, Nobuya

AU - Akiyoshi, Tsuyoshi

AU - Barnard, Graham F.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Integrin α6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin α6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumors. Concerning the variant, there was a significant correlation between the expression ratio of variant B/variant A and the depth of tumor invasion. In conclusion, i) integrin α6 expression was intimately correlated with histologic differentiation, and ii) the overexpression of variant B may be correlated with tumor invasion of gastric carcinoma.

AB - Integrin α6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin α6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumors. Concerning the variant, there was a significant correlation between the expression ratio of variant B/variant A and the depth of tumor invasion. In conclusion, i) integrin α6 expression was intimately correlated with histologic differentiation, and ii) the overexpression of variant B may be correlated with tumor invasion of gastric carcinoma.

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M3 - Article

C2 - 21528290

AN - SCOPUS:0030850480

SN - 1019-6439

VL - 11

SP - 959

EP - 964

JO - International Journal of Oncology

JF - International Journal of Oncology

IS - 5

ER -

Clinical significance of integrin α6 mRNA expression in gastric carcinoma

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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