Clinical significance of integrin α6 mRNA expression in gastric carcinoma

Koshi Mimori, Masaki Mori, Nasim A. Begum, Shinji Tanaka, Masaru Haraguchi, Hiroaki Ueo, Nobuya Karimine, Tsuyoshi Akiyoshi, Graham F. Barnard

Research output: Contribution to journalArticle

Abstract

Integrin α6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin α6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumors. Concerning the variant, there was a significant correlation between the expression ratio of variant B/variant A and the depth of tumor invasion. In conclusion, i) integrin α6 expression was intimately correlated with histologic differentiation, and ii) the overexpression of variant B may be correlated with tumor invasion of gastric carcinoma.

Original languageEnglish
Pages (from-to)959-964
Number of pages6
JournalInternational journal of oncology
Volume11
Issue number5
Publication statusPublished - Jan 1 1997

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Mimori, K., Mori, M., Begum, N. A., Tanaka, S., Haraguchi, M., Ueo, H., ... Barnard, G. F. (1997). Clinical significance of integrin α6 mRNA expression in gastric carcinoma. International journal of oncology, 11(5), 959-964.