Clinical significance of invasion distance relative to prognosis in pathological T3 colorectal cancer

Masatoshi Nomura, Hidekazu Takahashi, Makoto Fujii, Norikatsu Miyoshi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki

Research output: Contribution to journalArticle

Abstract

The T3 subdivision has been reported to predict prognosis in rectal cancer. However, few studies describe a correlation between T3 subdivision and prognosis in colon cancer. The current study aimed validate the correlation between the invasion distance (ID) beyond the muscularis propria and prognosis in colorectal cancer. The present retrospective study included 148 consecutive patients with pathologically confirmed T3 colorectal cancer, who underwent resection between January 2008 and October 2012. T3 stage was subdivided based on ID: T3a, ID<1 mm; T3b, ID=1-5 mm; and T3c, ID>5 mm. Statistical analyses were performed to evaluate correlations between T3 subdivision groups (T3a + T3b versus T3c) and clinicopathological factors. Compared with the T3a + T3b group, the T3c group exhibited worse 3-year RFS (P=0.003) and 5-year CSS (P=0.006). Multivariate analysis demonstrated that 3-year RFS was significantly correlated with sex (P=0.03) and ID (P=0.02), and 5-year CSS was significantly correlated with lymphoid dissection number (P=0.02) and ID (P=0.03). A ROC curve was constructed using ID values and recurrence data, and the area under the curve was 0.63. These data revealed that ID beyond the muscularis propria was significantly associated with prognosis in T3 colorectal cancer.

Original languageEnglish
Pages (from-to)5614-5620
Number of pages7
JournalOncology Letters
Volume18
Issue number5
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Colorectal Neoplasms
Rectal Neoplasms
ROC Curve
Colonic Neoplasms
Area Under Curve
Dissection
Multivariate Analysis
Retrospective Studies
Recurrence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Nomura, M., Takahashi, H., Fujii, M., Miyoshi, N., Haraguchi, N., Hata, T., ... Doki, Y. (2019). Clinical significance of invasion distance relative to prognosis in pathological T3 colorectal cancer. Oncology Letters, 18(5), 5614-5620. https://doi.org/10.3892/ol.2019.10913

Clinical significance of invasion distance relative to prognosis in pathological T3 colorectal cancer. / Nomura, Masatoshi; Takahashi, Hidekazu; Fujii, Makoto; Miyoshi, Norikatsu; Haraguchi, Naotsugu; Hata, Taishi; Matsuda, Chu; Yamamoto, Hirofumi; Mizushima, Tsunekazu; Mori, Masaki; Doki, Yuichiro.

In: Oncology Letters, Vol. 18, No. 5, 01.01.2019, p. 5614-5620.

Research output: Contribution to journalArticle

Nomura, M, Takahashi, H, Fujii, M, Miyoshi, N, Haraguchi, N, Hata, T, Matsuda, C, Yamamoto, H, Mizushima, T, Mori, M & Doki, Y 2019, 'Clinical significance of invasion distance relative to prognosis in pathological T3 colorectal cancer', Oncology Letters, vol. 18, no. 5, pp. 5614-5620. https://doi.org/10.3892/ol.2019.10913
Nomura, Masatoshi ; Takahashi, Hidekazu ; Fujii, Makoto ; Miyoshi, Norikatsu ; Haraguchi, Naotsugu ; Hata, Taishi ; Matsuda, Chu ; Yamamoto, Hirofumi ; Mizushima, Tsunekazu ; Mori, Masaki ; Doki, Yuichiro. / Clinical significance of invasion distance relative to prognosis in pathological T3 colorectal cancer. In: Oncology Letters. 2019 ; Vol. 18, No. 5. pp. 5614-5620.
@article{9a92e3742d0d4efa86c8c1eb6f6422cc,
title = "Clinical significance of invasion distance relative to prognosis in pathological T3 colorectal cancer",
abstract = "The T3 subdivision has been reported to predict prognosis in rectal cancer. However, few studies describe a correlation between T3 subdivision and prognosis in colon cancer. The current study aimed validate the correlation between the invasion distance (ID) beyond the muscularis propria and prognosis in colorectal cancer. The present retrospective study included 148 consecutive patients with pathologically confirmed T3 colorectal cancer, who underwent resection between January 2008 and October 2012. T3 stage was subdivided based on ID: T3a, ID<1 mm; T3b, ID=1-5 mm; and T3c, ID>5 mm. Statistical analyses were performed to evaluate correlations between T3 subdivision groups (T3a + T3b versus T3c) and clinicopathological factors. Compared with the T3a + T3b group, the T3c group exhibited worse 3-year RFS (P=0.003) and 5-year CSS (P=0.006). Multivariate analysis demonstrated that 3-year RFS was significantly correlated with sex (P=0.03) and ID (P=0.02), and 5-year CSS was significantly correlated with lymphoid dissection number (P=0.02) and ID (P=0.03). A ROC curve was constructed using ID values and recurrence data, and the area under the curve was 0.63. These data revealed that ID beyond the muscularis propria was significantly associated with prognosis in T3 colorectal cancer.",
author = "Masatoshi Nomura and Hidekazu Takahashi and Makoto Fujii and Norikatsu Miyoshi and Naotsugu Haraguchi and Taishi Hata and Chu Matsuda and Hirofumi Yamamoto and Tsunekazu Mizushima and Masaki Mori and Yuichiro Doki",
year = "2019",
month = "1",
day = "1",
doi = "10.3892/ol.2019.10913",
language = "English",
volume = "18",
pages = "5614--5620",
journal = "Oncology Letters",
issn = "1792-1074",
publisher = "Spandidos Publications",
number = "5",

}

TY - JOUR

T1 - Clinical significance of invasion distance relative to prognosis in pathological T3 colorectal cancer

AU - Nomura, Masatoshi

AU - Takahashi, Hidekazu

AU - Fujii, Makoto

AU - Miyoshi, Norikatsu

AU - Haraguchi, Naotsugu

AU - Hata, Taishi

AU - Matsuda, Chu

AU - Yamamoto, Hirofumi

AU - Mizushima, Tsunekazu

AU - Mori, Masaki

AU - Doki, Yuichiro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The T3 subdivision has been reported to predict prognosis in rectal cancer. However, few studies describe a correlation between T3 subdivision and prognosis in colon cancer. The current study aimed validate the correlation between the invasion distance (ID) beyond the muscularis propria and prognosis in colorectal cancer. The present retrospective study included 148 consecutive patients with pathologically confirmed T3 colorectal cancer, who underwent resection between January 2008 and October 2012. T3 stage was subdivided based on ID: T3a, ID<1 mm; T3b, ID=1-5 mm; and T3c, ID>5 mm. Statistical analyses were performed to evaluate correlations between T3 subdivision groups (T3a + T3b versus T3c) and clinicopathological factors. Compared with the T3a + T3b group, the T3c group exhibited worse 3-year RFS (P=0.003) and 5-year CSS (P=0.006). Multivariate analysis demonstrated that 3-year RFS was significantly correlated with sex (P=0.03) and ID (P=0.02), and 5-year CSS was significantly correlated with lymphoid dissection number (P=0.02) and ID (P=0.03). A ROC curve was constructed using ID values and recurrence data, and the area under the curve was 0.63. These data revealed that ID beyond the muscularis propria was significantly associated with prognosis in T3 colorectal cancer.

AB - The T3 subdivision has been reported to predict prognosis in rectal cancer. However, few studies describe a correlation between T3 subdivision and prognosis in colon cancer. The current study aimed validate the correlation between the invasion distance (ID) beyond the muscularis propria and prognosis in colorectal cancer. The present retrospective study included 148 consecutive patients with pathologically confirmed T3 colorectal cancer, who underwent resection between January 2008 and October 2012. T3 stage was subdivided based on ID: T3a, ID<1 mm; T3b, ID=1-5 mm; and T3c, ID>5 mm. Statistical analyses were performed to evaluate correlations between T3 subdivision groups (T3a + T3b versus T3c) and clinicopathological factors. Compared with the T3a + T3b group, the T3c group exhibited worse 3-year RFS (P=0.003) and 5-year CSS (P=0.006). Multivariate analysis demonstrated that 3-year RFS was significantly correlated with sex (P=0.03) and ID (P=0.02), and 5-year CSS was significantly correlated with lymphoid dissection number (P=0.02) and ID (P=0.03). A ROC curve was constructed using ID values and recurrence data, and the area under the curve was 0.63. These data revealed that ID beyond the muscularis propria was significantly associated with prognosis in T3 colorectal cancer.

UR - http://www.scopus.com/inward/record.url?scp=85073716514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073716514&partnerID=8YFLogxK

U2 - 10.3892/ol.2019.10913

DO - 10.3892/ol.2019.10913

M3 - Article

AN - SCOPUS:85073716514

VL - 18

SP - 5614

EP - 5620

JO - Oncology Letters

JF - Oncology Letters

SN - 1792-1074

IS - 5

ER -