Clinical significance of MT1-MMP mRNA expression in breast cancer

Research output: Contribution to journalArticle

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Abstract

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is known as an activator of MMP-2. We reported that the expression of MT1-MMP is a powerful indicator of lymph node metastasis in gastric cancers. We now examined the possibility that MT1-MMP expression also is an indicator of lymph node metastasis in breast cancer. We examined the clinicopathologic significance of the expression of MT1-MMP mRNA in 53 breast cancer specimens by the semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) assay. The highest expression of MT1-MMP was found in those specimens showing lymph node metastasis and/or lymph vessel invasion. Therefore, an analysis of MT1-MMP can predict the presence of lymph node metastasis in breast cancer patients by RT-PCR assay in minute amounts of tissue. We believe this is an objective assay for determining the role of MT1-MMP for metastasis in patients with breast cancer.

Original languageEnglish
Pages (from-to)401-403
Number of pages3
JournalOncology Reports
Volume8
Issue number2
Publication statusPublished - Dec 1 2001

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Matrix Metalloproteinase 14
Breast Neoplasms
Messenger RNA
Neoplasm Metastasis
Lymph Nodes
Reverse Transcriptase Polymerase Chain Reaction
Lymph
Matrix Metalloproteinases
Stomach Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Clinical significance of MT1-MMP mRNA expression in breast cancer. / Mimori, Koshi.

In: Oncology Reports, Vol. 8, No. 2, 01.12.2001, p. 401-403.

Research output: Contribution to journalArticle

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