Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer

Shinkichi Takamori, Gouji Toyokawa, Isamu Okamoto, Kazuki Takada, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Nobutaka Mukae, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Toru Iwaki, Koji Iihara, Yoichi Nakanishi, Yoshihiko Maehara

Research output: Contribution to journalArticle

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Abstract

Aim: To investigate the association between positivity for programmed cell death-ligand 1 (PD-L1) in brain metastases (BM) and the prognosis or clinical factors in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Thirty-two patients with surgically resected brain-metastatic NSCLC were enrolled. The PD-L1 expression in BM was analyzed using the antibody against human PD-L1 (clone SP142). The PD-L1 positivity was defined as PD-L1 expression on brain-metastatic tumor cells of =5%. Results: Seven (21.9%) out of 32 patients showed PD-L1 positivity in BM. The PD-L1-positive BM group had a significantly shorter brain-specific disease-free survival than the PD-L1-negative BM group (p<0.05). PD-L1 positivity in BM was significantly associated with a heavy smoking history and the administration of radiotherapy for BM before surgery (p<0.05 and p<0.05, respectively). Conclusion: The PD-L1 expression in BM from NSCLC may be associated with local recurrence following surgery, and the smoking- or radiotherapy-derived effects.

Original languageEnglish
Pages (from-to)553-557
Number of pages5
JournalAnticancer research
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

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Non-Small Cell Lung Carcinoma
Cell Death
Neoplasm Metastasis
Ligands
Brain
Radiotherapy
Smoking
Brain Diseases
Brain Neoplasms
Disease-Free Survival
Clone Cells
History
Recurrence
Antibodies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Takamori, S., Toyokawa, G., Okamoto, I., Takada, K., Kinoshita, F., Kozuma, Y., ... Maehara, Y. (2018). Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer. Anticancer research, 38(1), 553-557. https://doi.org/10.21873/anticanres.12258

Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer. / Takamori, Shinkichi; Toyokawa, Gouji; Okamoto, Isamu; Takada, Kazuki; Kinoshita, Fumihiko; Kozuma, Yuka; Matsubara, Taichi; Haratake, Naoki; Akamine, Takaki; Mukae, Nobutaka; Hirai, Fumihiko; Tagawa, Tetsuzo; Oda, Yoshinao; Iwaki, Toru; Iihara, Koji; Nakanishi, Yoichi; Maehara, Yoshihiko.

In: Anticancer research, Vol. 38, No. 1, 01.01.2018, p. 553-557.

Research output: Contribution to journalArticle

Takamori, S, Toyokawa, G, Okamoto, I, Takada, K, Kinoshita, F, Kozuma, Y, Matsubara, T, Haratake, N, Akamine, T, Mukae, N, Hirai, F, Tagawa, T, Oda, Y, Iwaki, T, Iihara, K, Nakanishi, Y & Maehara, Y 2018, 'Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer', Anticancer research, vol. 38, no. 1, pp. 553-557. https://doi.org/10.21873/anticanres.12258
Takamori, Shinkichi ; Toyokawa, Gouji ; Okamoto, Isamu ; Takada, Kazuki ; Kinoshita, Fumihiko ; Kozuma, Yuka ; Matsubara, Taichi ; Haratake, Naoki ; Akamine, Takaki ; Mukae, Nobutaka ; Hirai, Fumihiko ; Tagawa, Tetsuzo ; Oda, Yoshinao ; Iwaki, Toru ; Iihara, Koji ; Nakanishi, Yoichi ; Maehara, Yoshihiko. / Clinical significance of PD-L1 expression in brain metastases from non-small cell lung cancer. In: Anticancer research. 2018 ; Vol. 38, No. 1. pp. 553-557.
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AU - Toyokawa, Gouji

AU - Okamoto, Isamu

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AU - Kinoshita, Fumihiko

AU - Kozuma, Yuka

AU - Matsubara, Taichi

AU - Haratake, Naoki

AU - Akamine, Takaki

AU - Mukae, Nobutaka

AU - Hirai, Fumihiko

AU - Tagawa, Tetsuzo

AU - Oda, Yoshinao

AU - Iwaki, Toru

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AU - Nakanishi, Yoichi

AU - Maehara, Yoshihiko

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N2 - Aim: To investigate the association between positivity for programmed cell death-ligand 1 (PD-L1) in brain metastases (BM) and the prognosis or clinical factors in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Thirty-two patients with surgically resected brain-metastatic NSCLC were enrolled. The PD-L1 expression in BM was analyzed using the antibody against human PD-L1 (clone SP142). The PD-L1 positivity was defined as PD-L1 expression on brain-metastatic tumor cells of =5%. Results: Seven (21.9%) out of 32 patients showed PD-L1 positivity in BM. The PD-L1-positive BM group had a significantly shorter brain-specific disease-free survival than the PD-L1-negative BM group (p<0.05). PD-L1 positivity in BM was significantly associated with a heavy smoking history and the administration of radiotherapy for BM before surgery (p<0.05 and p<0.05, respectively). Conclusion: The PD-L1 expression in BM from NSCLC may be associated with local recurrence following surgery, and the smoking- or radiotherapy-derived effects.

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