Clinical significance of pyrimidine nucleoside phosphorylase in colorectal carcinoma

Koshi Mimori, Masaki Mori, Takeshi Shiraishi, Masaru Haraguchi, Hiroaki Ueo, Tsuyoshi Akiyoshi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The expression of pyrimidine nucleoside phosphorylase (PyNPase) mRNA in tumor (T) and normal (N) biopsy specimens obtained from 41 cases of colorectal carcinoma was examined by the reverse transcriptase-polymerase chain reaction (RT-PCR). The higher T/N ratio of the expression of PyNPase mRNA correlated significantly with the presence of lymph vessel invasion (p = 0.039), the positive lymph node metastasis (p = 0.014) and the advanced stage of the disease (p = 0.014). There was a significant correlation between the results determined by enzyme activity and those determined by RT-PCR (p = 0.005). The findings suggested that the determination of PyNPase mRNA by RT-PCR may give useful information on tumor aggressiveness of colorectal carcinoma and this method can be used instead of enzyme activity.

Original languageEnglish
Pages (from-to)493-496
Number of pages4
JournalInternational journal of oncology
Volume10
Issue number3
Publication statusPublished - Mar 1 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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