Clinical significance of surgical resection of metastatic lymph nodes from hepatocellular carcinoma

Yoshito Tomimaru, Hiroshi Wada, Hidetoshi Eguchi, Akira Tomokuni, Naoki Hama, Koichi Kawamoto, Shigeru Marubashi, Koji Umeshita, Yuichiro Doki, Masaki Mori, Kenichi Wakasa, Hiroaki Nagano

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: The clinical significance of the surgical resection of metastatic lymph nodes (LN) from patients with hepatocellular carcinoma (HCC) remains controversial. The aim of this study was to evaluate the significance of the surgical resection of LN metastasis of HCC. Methods: Among 961 patients who underwent surgical resection for HCC in our hospital, LN metastasis was identified in 38 patients. In these patients, the metastatic LN were removed completely in 22 patients (complete removal group), and incompletely or not removed in 16 patients (control group). The long-term prognosis after LN metastasis was compared between the two groups. Results: The overall survival rate after LN metastasis was significantly better in the complete removal group (1-, 3- and 5-year: 71.2, 58.0 and 49.7 %, respectively) than in the control group (45.9, 23.0 and 15.3 %, respectively, p = 0.0477). LN metastasis was not the cause of death in any of the patients in the complete removal group, whereas it was a cause in some patients in the control group. No local LN recurrence was identified in the complete removal group. Conclusions: The present results suggest that the complete removal of metastatic LN from HCC is clinically beneficial in selected patients.

Original languageEnglish
Pages (from-to)1112-1120
Number of pages9
JournalSurgery today
Volume45
Issue number9
DOIs
Publication statusPublished - Sep 17 2015
Externally publishedYes

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Hepatocellular Carcinoma
Lymph Nodes
Neoplasm Metastasis
Control Groups
Cause of Death
Survival Rate
Recurrence

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Tomimaru, Y., Wada, H., Eguchi, H., Tomokuni, A., Hama, N., Kawamoto, K., ... Nagano, H. (2015). Clinical significance of surgical resection of metastatic lymph nodes from hepatocellular carcinoma. Surgery today, 45(9), 1112-1120. https://doi.org/10.1007/s00595-014-1028-8

Clinical significance of surgical resection of metastatic lymph nodes from hepatocellular carcinoma. / Tomimaru, Yoshito; Wada, Hiroshi; Eguchi, Hidetoshi; Tomokuni, Akira; Hama, Naoki; Kawamoto, Koichi; Marubashi, Shigeru; Umeshita, Koji; Doki, Yuichiro; Mori, Masaki; Wakasa, Kenichi; Nagano, Hiroaki.

In: Surgery today, Vol. 45, No. 9, 17.09.2015, p. 1112-1120.

Research output: Contribution to journalArticle

Tomimaru, Y, Wada, H, Eguchi, H, Tomokuni, A, Hama, N, Kawamoto, K, Marubashi, S, Umeshita, K, Doki, Y, Mori, M, Wakasa, K & Nagano, H 2015, 'Clinical significance of surgical resection of metastatic lymph nodes from hepatocellular carcinoma', Surgery today, vol. 45, no. 9, pp. 1112-1120. https://doi.org/10.1007/s00595-014-1028-8
Tomimaru, Yoshito ; Wada, Hiroshi ; Eguchi, Hidetoshi ; Tomokuni, Akira ; Hama, Naoki ; Kawamoto, Koichi ; Marubashi, Shigeru ; Umeshita, Koji ; Doki, Yuichiro ; Mori, Masaki ; Wakasa, Kenichi ; Nagano, Hiroaki. / Clinical significance of surgical resection of metastatic lymph nodes from hepatocellular carcinoma. In: Surgery today. 2015 ; Vol. 45, No. 9. pp. 1112-1120.
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AU - Tomimaru, Yoshito

AU - Wada, Hiroshi

AU - Eguchi, Hidetoshi

AU - Tomokuni, Akira

AU - Hama, Naoki

AU - Kawamoto, Koichi

AU - Marubashi, Shigeru

AU - Umeshita, Koji

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Wakasa, Kenichi

AU - Nagano, Hiroaki

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N2 - Purpose: The clinical significance of the surgical resection of metastatic lymph nodes (LN) from patients with hepatocellular carcinoma (HCC) remains controversial. The aim of this study was to evaluate the significance of the surgical resection of LN metastasis of HCC. Methods: Among 961 patients who underwent surgical resection for HCC in our hospital, LN metastasis was identified in 38 patients. In these patients, the metastatic LN were removed completely in 22 patients (complete removal group), and incompletely or not removed in 16 patients (control group). The long-term prognosis after LN metastasis was compared between the two groups. Results: The overall survival rate after LN metastasis was significantly better in the complete removal group (1-, 3- and 5-year: 71.2, 58.0 and 49.7 %, respectively) than in the control group (45.9, 23.0 and 15.3 %, respectively, p = 0.0477). LN metastasis was not the cause of death in any of the patients in the complete removal group, whereas it was a cause in some patients in the control group. No local LN recurrence was identified in the complete removal group. Conclusions: The present results suggest that the complete removal of metastatic LN from HCC is clinically beneficial in selected patients.

AB - Purpose: The clinical significance of the surgical resection of metastatic lymph nodes (LN) from patients with hepatocellular carcinoma (HCC) remains controversial. The aim of this study was to evaluate the significance of the surgical resection of LN metastasis of HCC. Methods: Among 961 patients who underwent surgical resection for HCC in our hospital, LN metastasis was identified in 38 patients. In these patients, the metastatic LN were removed completely in 22 patients (complete removal group), and incompletely or not removed in 16 patients (control group). The long-term prognosis after LN metastasis was compared between the two groups. Results: The overall survival rate after LN metastasis was significantly better in the complete removal group (1-, 3- and 5-year: 71.2, 58.0 and 49.7 %, respectively) than in the control group (45.9, 23.0 and 15.3 %, respectively, p = 0.0477). LN metastasis was not the cause of death in any of the patients in the complete removal group, whereas it was a cause in some patients in the control group. No local LN recurrence was identified in the complete removal group. Conclusions: The present results suggest that the complete removal of metastatic LN from HCC is clinically beneficial in selected patients.

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