Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer

J. Kinoshita, K. Kitamura, Akira Kabashima, Hiroshi Saeki, S. Tanaka, K. Sugimachi

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Vascular endothelial growth factor-C (VEGF-C) is a specific ligand which induces lymphangiogenesis. We examined the expression of VEGF-C protein to determine its role in the progression of breast cancer. Immunohistochemical analysis revealed that VEGF-C was overexpressed in 39 of 98 breast cancer specimens (39.8%) but not in adjacent normal mammary glands. The expression of VEGF-C showed a significant correlation with lymphatic vessel invasion (p = 0.0004). It is noteworthy that the 5-year disease free survival rate of the VEGF-C positive group was significantly poorer than that of negative group (p = 0.0356). We suggest that as expression of VEGF-C is not implicated in lymphatic spread, it may prove to be a promising marker to predict the recurrence of breast cancer.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalBreast Cancer Research and Treatment
Volume66
Issue number2
DOIs
Publication statusPublished - Jun 21 2001

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Vascular Endothelial Growth Factor C
Breast Neoplasms
Lymphangiogenesis
Lymphatic Vessels
Human Mammary Glands
Disease-Free Survival
Ligands
Recurrence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kinoshita, J., Kitamura, K., Kabashima, A., Saeki, H., Tanaka, S., & Sugimachi, K. (2001). Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer. Breast Cancer Research and Treatment, 66(2), 159-164. https://doi.org/10.1023/A:1010692132669

Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer. / Kinoshita, J.; Kitamura, K.; Kabashima, Akira; Saeki, Hiroshi; Tanaka, S.; Sugimachi, K.

In: Breast Cancer Research and Treatment, Vol. 66, No. 2, 21.06.2001, p. 159-164.

Research output: Contribution to journalArticle

Kinoshita, J, Kitamura, K, Kabashima, A, Saeki, H, Tanaka, S & Sugimachi, K 2001, 'Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer', Breast Cancer Research and Treatment, vol. 66, no. 2, pp. 159-164. https://doi.org/10.1023/A:1010692132669
Kinoshita, J. ; Kitamura, K. ; Kabashima, Akira ; Saeki, Hiroshi ; Tanaka, S. ; Sugimachi, K. / Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer. In: Breast Cancer Research and Treatment. 2001 ; Vol. 66, No. 2. pp. 159-164.
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