TY - JOUR
T1 - Clinical significances of preoperative classification of intrahepatic cholangiocarcinoma
T2 - Different characteristics of perihilar vs. Peripheral ICC
AU - Yamashita, Yo Ichi
AU - Wang, Huanlin
AU - Kurihara, Takeshi
AU - Tsujita, Eiji
AU - Nishie, Akihiro
AU - Imai, Katsunori
AU - Hashimoto, Daisuke
AU - Chikamoto, Akira
AU - Aishima, Shinichi
AU - Baba, Hideo
PY - 2016/12
Y1 - 2016/12
N2 - Background: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). Patients and Methods: A retrospective cohort study was performed to analyze the differences in clinical characteristics between perihilar and peripheral ICC samples from patients between 1990-2014. Results: A total of 87 patients were divided into three ICC subtypes; perihilar (n=34), peripheral (n=44), and unclassifiable ICC (n=9). The positive rates of pathological lymphatic infiltration (ly) (p=0.02) and perineural invasion (pn) (p<0.0001) were significantly higher in perihilar ICC. There was no significant difference in the disease-free survival rate (p=0.2268); however, the overall survival rate of perihilar ICC was significantly worse (p=0.0031). The rate of systemic recurrence (>3 nodules) was significantly higher in perihilar ICC (p=0.0135). Conclusion: In perihilar ICC, the local tumor invasions such as ly and pn were more frequent. Therefore, it is important in such cases to attempt to achieve a sufficient tumor margin. Systemic recurrences were more frequent in perihilar ICC, so perioperative chemotherapy should be conducted as well.
AB - Background: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). Patients and Methods: A retrospective cohort study was performed to analyze the differences in clinical characteristics between perihilar and peripheral ICC samples from patients between 1990-2014. Results: A total of 87 patients were divided into three ICC subtypes; perihilar (n=34), peripheral (n=44), and unclassifiable ICC (n=9). The positive rates of pathological lymphatic infiltration (ly) (p=0.02) and perineural invasion (pn) (p<0.0001) were significantly higher in perihilar ICC. There was no significant difference in the disease-free survival rate (p=0.2268); however, the overall survival rate of perihilar ICC was significantly worse (p=0.0031). The rate of systemic recurrence (>3 nodules) was significantly higher in perihilar ICC (p=0.0135). Conclusion: In perihilar ICC, the local tumor invasions such as ly and pn were more frequent. Therefore, it is important in such cases to attempt to achieve a sufficient tumor margin. Systemic recurrences were more frequent in perihilar ICC, so perioperative chemotherapy should be conducted as well.
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U2 - 10.21873/anticanres.11260
DO - 10.21873/anticanres.11260
M3 - Article
C2 - 27919984
AN - SCOPUS:85001969708
SN - 0250-7005
VL - 36
SP - 6563
EP - 6569
JO - Anticancer Research
JF - Anticancer Research
IS - 12
ER -
