Clinical significances of preoperative classification of intrahepatic cholangiocarcinoma: Different characteristics of perihilar vs. Peripheral ICC

Yo Ichi Yamashita, Huanlin Wang, Takeshi Kurihara, Eiji Tsujita, Akihiro Nishie, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Shinichi Aishima, Hideo Baba

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). Patients and Methods: A retrospective cohort study was performed to analyze the differences in clinical characteristics between perihilar and peripheral ICC samples from patients between 1990-2014. Results: A total of 87 patients were divided into three ICC subtypes; perihilar (n=34), peripheral (n=44), and unclassifiable ICC (n=9). The positive rates of pathological lymphatic infiltration (ly) (p=0.02) and perineural invasion (pn) (p<0.0001) were significantly higher in perihilar ICC. There was no significant difference in the disease-free survival rate (p=0.2268); however, the overall survival rate of perihilar ICC was significantly worse (p=0.0031). The rate of systemic recurrence (>3 nodules) was significantly higher in perihilar ICC (p=0.0135). Conclusion: In perihilar ICC, the local tumor invasions such as ly and pn were more frequent. Therefore, it is important in such cases to attempt to achieve a sufficient tumor margin. Systemic recurrences were more frequent in perihilar ICC, so perioperative chemotherapy should be conducted as well.

Original languageEnglish
Pages (from-to)6563-6569
Number of pages7
JournalAnticancer research
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

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Cholangiocarcinoma
Klatskin Tumor
Neoplasms
Cohort Studies
Retrospective Studies
Tomography
Recurrence
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Clinical significances of preoperative classification of intrahepatic cholangiocarcinoma : Different characteristics of perihilar vs. Peripheral ICC. / Yamashita, Yo Ichi; Wang, Huanlin; Kurihara, Takeshi; Tsujita, Eiji; Nishie, Akihiro; Imai, Katsunori; Hashimoto, Daisuke; Chikamoto, Akira; Aishima, Shinichi; Baba, Hideo.

In: Anticancer research, Vol. 36, No. 12, 01.12.2016, p. 6563-6569.

Research output: Contribution to journalArticle

Yamashita, YI, Wang, H, Kurihara, T, Tsujita, E, Nishie, A, Imai, K, Hashimoto, D, Chikamoto, A, Aishima, S & Baba, H 2016, 'Clinical significances of preoperative classification of intrahepatic cholangiocarcinoma: Different characteristics of perihilar vs. Peripheral ICC', Anticancer research, vol. 36, no. 12, pp. 6563-6569. https://doi.org/10.21873/anticanres.11260
Yamashita, Yo Ichi ; Wang, Huanlin ; Kurihara, Takeshi ; Tsujita, Eiji ; Nishie, Akihiro ; Imai, Katsunori ; Hashimoto, Daisuke ; Chikamoto, Akira ; Aishima, Shinichi ; Baba, Hideo. / Clinical significances of preoperative classification of intrahepatic cholangiocarcinoma : Different characteristics of perihilar vs. Peripheral ICC. In: Anticancer research. 2016 ; Vol. 36, No. 12. pp. 6563-6569.
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