Clinical Studies on Itraconazole

Koji Takaki, Yoshiro Sawae, Kaoru Okada, Nobuyuki Shimono, Hiroyasu Misumi

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Abstract

We performed clinical studies on itraconazole, a new triazole antifungal agent. Four patients suffering from candidemia, pulmonary aspergillosis, oral thrush, and urinary tract infection due to Trichosporon cutaneum were treated with itraconazole at a single daily dose of 100-200 mg for 9-31 days. Clinical response was good in all patients. Bacteriological effect was eradicated in 2 cases, diminished in one and unknown in one. No side effect was observed and there were no abnormal laboratory findings. A suspected case of pulmonary cryptococcosis tolerated long-term administration of itraconazole at a daily dose of 100-150 mg for 198 days without observable adverse reactions.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalNippon Ishinkin Gakkai Zasshi
Volume32
Issue number4
DOIs
Publication statusPublished - Jan 1 1991

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All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases

Cite this

Takaki, K., Sawae, Y., Okada, K., Shimono, N., & Misumi, H. (1991). Clinical Studies on Itraconazole. Nippon Ishinkin Gakkai Zasshi, 32(4), 273-278. https://doi.org/10.3314/jjmm.32.273