Clinical study of azithromycin

Yoshiro Sawae, Hiroyasu Misumi, Koji Takaki, Toshiyuki Ishimaru, Masaharu Motomura, Yukio Kumagai, Makoto Katsuno, Nobuyuki Shimono, Hiroshi Inoue, Ikuo Sumita, Takatoshi Inoue

Research output: Contribution to journalArticle

Abstract

A clinical study of azithromycin (AZM), a newly developed oral macrolide antibacterial agent, was performed with the following results. AZM at a dose of 250 or 500 mg was administered once a day for 3 days to 22 patients, including 1 case of pharyngolaryngitis, 4 of acute bronchitis and 17 of pneumonia. The clinical effect was evaluated as excellent in 5, good in 13, poor in 1 and undetermined in 3 cases. Adverse reactions thought to have a causal relationship to AZM included coughing, dyspnea and fever in 1 case and a rigidity of anterior chest in 1 case. However, these symptoms disappeared within 1 month after the administration of AZM. Abnormal laboratory values due to drug administration were observed in 3 cases: increased eosinophils in 2, elevated GOT, GPT, ALP, γ-GTP, CRP and ESR in 1.

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalJapanese Journal of Chemotherapy
Volume43
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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    Sawae, Y., Misumi, H., Takaki, K., Ishimaru, T., Motomura, M., Kumagai, Y., Katsuno, M., Shimono, N., Inoue, H., Sumita, I., & Inoue, T. (1995). Clinical study of azithromycin. Japanese Journal of Chemotherapy, 43, 415-419. https://doi.org/10.11250/chemotherapy1995.43.Supplement6_415