Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan

Hiroyuki Torisu, Ryutaro Kira, Yoshito Ishizaki, Masafumi Sanefuji, Yui Yamaguchi, Sawa Yasumoto, Yoshihiko Murakami, Masayuki Shimono, Shinichiro Nagamitsu, Mayumi Masuzaki, Masano Amamoto, Rikako Kondo, Tomohiko Uozumi, Miyuki Aibe, Kenjiro Gondo, Toshio Hanai, Sinichi Hirose, Toyojiro Matsuishi, Akira Shirahata, Akihisa MitsudomeToshiro Hara

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Abstract

Acute disseminated encephalomyelitis (ADEM) has recently been studied in several countries owing to the development and wide spread use of imaging technology, but few epidemiological studies of childhood ADEM have been undertaken in Asian countries. To perform a comprehensive survey of ADEM and related diseases in Japanese children, we conducted a multicenter, population-based study on childhood ADEM, multiple sclerosis, and acute isolated transverse myelitis in Fukuoka Prefecture, Japan. We identified 26 children with ADEM, 8 with multiple sclerosis, and 4 with acute transverse myelitis during 5. years between September 1998 and August 2003. The incidence of childhood ADEM under the age of 15. years was 0.64 per 100,000 person-years, mean age at onset was 5.7. years, and male-female ratio was 2.3:1. The prevalence of childhood multiple sclerosis was 1.3 per 100,000 persons. The mean age at onset of multiple sclerosis, 9.3. years, was significantly higher than that of ADEM. Nineteen (73%) and four (15%) patients with ADEM experienced antecedent infectious illnesses and vaccinations, respectively, within 1. month before the onset. Clinical and radiological findings of ADEM revealed that the frequency of seizures, mean white blood cell counts in cerebrospinal fluid, and the frequency of subcortical lesions in Fukuoka study, seemed to be higher than those in previous non-Asian studies. These findings suggest that there are ethnic or geographical differences in the incidence and clinical features of ADEM, and that there might be potent genetic or environmental risk factors for ADEM distinct from those for multiple sclerosis.

Original languageEnglish
Pages (from-to)454-462
Number of pages9
JournalBrain and Development
Volume32
Issue number6
DOIs
Publication statusPublished - Jun 1 2010

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Transverse Myelitis
Acute Disseminated Encephalomyelitis
Multiple Sclerosis
Japan
Age of Onset
Clinical Studies
Incidence
Leukocyte Count
Cerebrospinal Fluid
Epidemiologic Studies
Vaccination
Seizures

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan. / Torisu, Hiroyuki; Kira, Ryutaro; Ishizaki, Yoshito; Sanefuji, Masafumi; Yamaguchi, Yui; Yasumoto, Sawa; Murakami, Yoshihiko; Shimono, Masayuki; Nagamitsu, Shinichiro; Masuzaki, Mayumi; Amamoto, Masano; Kondo, Rikako; Uozumi, Tomohiko; Aibe, Miyuki; Gondo, Kenjiro; Hanai, Toshio; Hirose, Sinichi; Matsuishi, Toyojiro; Shirahata, Akira; Mitsudome, Akihisa; Hara, Toshiro.

In: Brain and Development, Vol. 32, No. 6, 01.06.2010, p. 454-462.

Research output: Contribution to journalArticle

Torisu, H, Kira, R, Ishizaki, Y, Sanefuji, M, Yamaguchi, Y, Yasumoto, S, Murakami, Y, Shimono, M, Nagamitsu, S, Masuzaki, M, Amamoto, M, Kondo, R, Uozumi, T, Aibe, M, Gondo, K, Hanai, T, Hirose, S, Matsuishi, T, Shirahata, A, Mitsudome, A & Hara, T 2010, 'Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan', Brain and Development, vol. 32, no. 6, pp. 454-462. https://doi.org/10.1016/j.braindev.2009.10.006
Torisu, Hiroyuki ; Kira, Ryutaro ; Ishizaki, Yoshito ; Sanefuji, Masafumi ; Yamaguchi, Yui ; Yasumoto, Sawa ; Murakami, Yoshihiko ; Shimono, Masayuki ; Nagamitsu, Shinichiro ; Masuzaki, Mayumi ; Amamoto, Masano ; Kondo, Rikako ; Uozumi, Tomohiko ; Aibe, Miyuki ; Gondo, Kenjiro ; Hanai, Toshio ; Hirose, Sinichi ; Matsuishi, Toyojiro ; Shirahata, Akira ; Mitsudome, Akihisa ; Hara, Toshiro. / Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan. In: Brain and Development. 2010 ; Vol. 32, No. 6. pp. 454-462.
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AU - Torisu, Hiroyuki

AU - Kira, Ryutaro

AU - Ishizaki, Yoshito

AU - Sanefuji, Masafumi

AU - Yamaguchi, Yui

AU - Yasumoto, Sawa

AU - Murakami, Yoshihiko

AU - Shimono, Masayuki

AU - Nagamitsu, Shinichiro

AU - Masuzaki, Mayumi

AU - Amamoto, Masano

AU - Kondo, Rikako

AU - Uozumi, Tomohiko

AU - Aibe, Miyuki

AU - Gondo, Kenjiro

AU - Hanai, Toshio

AU - Hirose, Sinichi

AU - Matsuishi, Toyojiro

AU - Shirahata, Akira

AU - Mitsudome, Akihisa

AU - Hara, Toshiro

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N2 - Acute disseminated encephalomyelitis (ADEM) has recently been studied in several countries owing to the development and wide spread use of imaging technology, but few epidemiological studies of childhood ADEM have been undertaken in Asian countries. To perform a comprehensive survey of ADEM and related diseases in Japanese children, we conducted a multicenter, population-based study on childhood ADEM, multiple sclerosis, and acute isolated transverse myelitis in Fukuoka Prefecture, Japan. We identified 26 children with ADEM, 8 with multiple sclerosis, and 4 with acute transverse myelitis during 5. years between September 1998 and August 2003. The incidence of childhood ADEM under the age of 15. years was 0.64 per 100,000 person-years, mean age at onset was 5.7. years, and male-female ratio was 2.3:1. The prevalence of childhood multiple sclerosis was 1.3 per 100,000 persons. The mean age at onset of multiple sclerosis, 9.3. years, was significantly higher than that of ADEM. Nineteen (73%) and four (15%) patients with ADEM experienced antecedent infectious illnesses and vaccinations, respectively, within 1. month before the onset. Clinical and radiological findings of ADEM revealed that the frequency of seizures, mean white blood cell counts in cerebrospinal fluid, and the frequency of subcortical lesions in Fukuoka study, seemed to be higher than those in previous non-Asian studies. These findings suggest that there are ethnic or geographical differences in the incidence and clinical features of ADEM, and that there might be potent genetic or environmental risk factors for ADEM distinct from those for multiple sclerosis.

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