Clinical tumor diameter and prognosis of patients with FIGO stage IB1 cervical cancer (JCOG0806-A)

Gynecologic Oncology Study Group of the Japan Clinical Oncology Group

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28 Citations (Scopus)

Abstract

Objective. In order to determine indications for less radical surgery such asmodified radical hysterectomy, the risk of pathological parametrial involvement and prognosis of FIGO stage IB1 cervical cancer patients undergoing standard radical hysterectomy with pre-operatively assessed tumor diameter ≤2 cm were investigated. Methods. We conducted a retrospective multi-institutional chart review of patients with FIGO stage IB1 cervical cancer who underwent primary surgical treatment between 1998 and 2002. The eligibility criteria for the analyses were (i) histologically-proven squamous cell carcinoma, adenocarcinoma or, adenosquamous cell carcinoma, (ii) radical hysterectomy performed, (iii) clinical tumor diameter data available byMR imaging or specimens by cone biopsy, and (iv) age between 20 and 70. Based on the clinical tumor diameter, patients were stratified into those with the following tumors: i) 2 cm or less (cT ≤ 2 cm) and ii) greater than 2 cm (cT > 2 cm).We expected 5-year OS of ≥95% and parametrial involvement <2-3% for patients with cT ≤ 2 cm who underwent radical hysterectomy. Results. Of the 1269 patients enrolled, 604 were eligible for the planned analyses. Among these, 571 underwent radical hysterectomy (323 with cT ≤ 2 cm and 248 with cT > 2 cm). Parametrial involvement was present in 1.9% (6/323) with cT ≤ 2 cm and 12.9% (32/248) with cT > 2 cm. Five-year overall survivals were 95.8% (95% CI 92.9-97.6%) in cT ≤ 2 cm and 91.9% (95% CI 87.6-94.8%) in cT > 2 cm patients. Conclusion. Patients with cT ≤ 2 cm had lower risk of parametrial involvement and more favorable 5-year overall survival. They could therefore be good candidates for receiving less radical surgery.

Original languageEnglish
Pages (from-to)34-39
Number of pages6
JournalGynecologic Oncology
Volume137
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Uterine Cervical Neoplasms
Hysterectomy
Neoplasms
Adenosquamous Carcinoma
Survival
Squamous Cell Carcinoma
Adenocarcinoma
Biopsy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Clinical tumor diameter and prognosis of patients with FIGO stage IB1 cervical cancer (JCOG0806-A). / Gynecologic Oncology Study Group of the Japan Clinical Oncology Group.

In: Gynecologic Oncology, Vol. 137, No. 1, 01.01.2015, p. 34-39.

Research output: Contribution to journalArticle

Gynecologic Oncology Study Group of the Japan Clinical Oncology Group 2015, 'Clinical tumor diameter and prognosis of patients with FIGO stage IB1 cervical cancer (JCOG0806-A)', Gynecologic Oncology, vol. 137, no. 1, pp. 34-39. https://doi.org/10.1016/j.ygyno.2015.01.548
Gynecologic Oncology Study Group of the Japan Clinical Oncology Group. / Clinical tumor diameter and prognosis of patients with FIGO stage IB1 cervical cancer (JCOG0806-A). In: Gynecologic Oncology. 2015 ; Vol. 137, No. 1. pp. 34-39.
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abstract = "Objective. In order to determine indications for less radical surgery such asmodified radical hysterectomy, the risk of pathological parametrial involvement and prognosis of FIGO stage IB1 cervical cancer patients undergoing standard radical hysterectomy with pre-operatively assessed tumor diameter ≤2 cm were investigated. Methods. We conducted a retrospective multi-institutional chart review of patients with FIGO stage IB1 cervical cancer who underwent primary surgical treatment between 1998 and 2002. The eligibility criteria for the analyses were (i) histologically-proven squamous cell carcinoma, adenocarcinoma or, adenosquamous cell carcinoma, (ii) radical hysterectomy performed, (iii) clinical tumor diameter data available byMR imaging or specimens by cone biopsy, and (iv) age between 20 and 70. Based on the clinical tumor diameter, patients were stratified into those with the following tumors: i) 2 cm or less (cT ≤ 2 cm) and ii) greater than 2 cm (cT > 2 cm).We expected 5-year OS of ≥95{\%} and parametrial involvement <2-3{\%} for patients with cT ≤ 2 cm who underwent radical hysterectomy. Results. Of the 1269 patients enrolled, 604 were eligible for the planned analyses. Among these, 571 underwent radical hysterectomy (323 with cT ≤ 2 cm and 248 with cT > 2 cm). Parametrial involvement was present in 1.9{\%} (6/323) with cT ≤ 2 cm and 12.9{\%} (32/248) with cT > 2 cm. Five-year overall survivals were 95.8{\%} (95{\%} CI 92.9-97.6{\%}) in cT ≤ 2 cm and 91.9{\%} (95{\%} CI 87.6-94.8{\%}) in cT > 2 cm patients. Conclusion. Patients with cT ≤ 2 cm had lower risk of parametrial involvement and more favorable 5-year overall survival. They could therefore be good candidates for receiving less radical surgery.",
author = "{Gynecologic Oncology Study Group of the Japan Clinical Oncology Group} and Tomoyasu Kato and Atsuo Takashima and Takahiro Kasamatsu and Kenichi Nakamura and Junki Mizusawa and Toru Nakanishi and Nobuhiro Takeshima and Shoji Kamiura and Takashi Onda and Toshiyuki Sumi and Masashi Takano and Hidekatsu Nakai and Toshiaki Saito and Kiyoshi Fujiwara and Masatoshi Yokoyama and Hiroaki Itamochi and Kazuhiro Takehara and Harushige Yokota and Tomoya Mizunoe and Satoru Takeda and Kenzo Sonoda and Tanri Shiozawa and Takayo Kawabata and Shigeru Honma and Haruhiko Fukuda and Nobuo Yaegashi and Hiroyuki Yoshikawa and Ikuo Konishi and Toshiharu Kamura",
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T1 - Clinical tumor diameter and prognosis of patients with FIGO stage IB1 cervical cancer (JCOG0806-A)

AU - Gynecologic Oncology Study Group of the Japan Clinical Oncology Group

AU - Kato, Tomoyasu

AU - Takashima, Atsuo

AU - Kasamatsu, Takahiro

AU - Nakamura, Kenichi

AU - Mizusawa, Junki

AU - Nakanishi, Toru

AU - Takeshima, Nobuhiro

AU - Kamiura, Shoji

AU - Onda, Takashi

AU - Sumi, Toshiyuki

AU - Takano, Masashi

AU - Nakai, Hidekatsu

AU - Saito, Toshiaki

AU - Fujiwara, Kiyoshi

AU - Yokoyama, Masatoshi

AU - Itamochi, Hiroaki

AU - Takehara, Kazuhiro

AU - Yokota, Harushige

AU - Mizunoe, Tomoya

AU - Takeda, Satoru

AU - Sonoda, Kenzo

AU - Shiozawa, Tanri

AU - Kawabata, Takayo

AU - Honma, Shigeru

AU - Fukuda, Haruhiko

AU - Yaegashi, Nobuo

AU - Yoshikawa, Hiroyuki

AU - Konishi, Ikuo

AU - Kamura, Toshiharu

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective. In order to determine indications for less radical surgery such asmodified radical hysterectomy, the risk of pathological parametrial involvement and prognosis of FIGO stage IB1 cervical cancer patients undergoing standard radical hysterectomy with pre-operatively assessed tumor diameter ≤2 cm were investigated. Methods. We conducted a retrospective multi-institutional chart review of patients with FIGO stage IB1 cervical cancer who underwent primary surgical treatment between 1998 and 2002. The eligibility criteria for the analyses were (i) histologically-proven squamous cell carcinoma, adenocarcinoma or, adenosquamous cell carcinoma, (ii) radical hysterectomy performed, (iii) clinical tumor diameter data available byMR imaging or specimens by cone biopsy, and (iv) age between 20 and 70. Based on the clinical tumor diameter, patients were stratified into those with the following tumors: i) 2 cm or less (cT ≤ 2 cm) and ii) greater than 2 cm (cT > 2 cm).We expected 5-year OS of ≥95% and parametrial involvement <2-3% for patients with cT ≤ 2 cm who underwent radical hysterectomy. Results. Of the 1269 patients enrolled, 604 were eligible for the planned analyses. Among these, 571 underwent radical hysterectomy (323 with cT ≤ 2 cm and 248 with cT > 2 cm). Parametrial involvement was present in 1.9% (6/323) with cT ≤ 2 cm and 12.9% (32/248) with cT > 2 cm. Five-year overall survivals were 95.8% (95% CI 92.9-97.6%) in cT ≤ 2 cm and 91.9% (95% CI 87.6-94.8%) in cT > 2 cm patients. Conclusion. Patients with cT ≤ 2 cm had lower risk of parametrial involvement and more favorable 5-year overall survival. They could therefore be good candidates for receiving less radical surgery.

AB - Objective. In order to determine indications for less radical surgery such asmodified radical hysterectomy, the risk of pathological parametrial involvement and prognosis of FIGO stage IB1 cervical cancer patients undergoing standard radical hysterectomy with pre-operatively assessed tumor diameter ≤2 cm were investigated. Methods. We conducted a retrospective multi-institutional chart review of patients with FIGO stage IB1 cervical cancer who underwent primary surgical treatment between 1998 and 2002. The eligibility criteria for the analyses were (i) histologically-proven squamous cell carcinoma, adenocarcinoma or, adenosquamous cell carcinoma, (ii) radical hysterectomy performed, (iii) clinical tumor diameter data available byMR imaging or specimens by cone biopsy, and (iv) age between 20 and 70. Based on the clinical tumor diameter, patients were stratified into those with the following tumors: i) 2 cm or less (cT ≤ 2 cm) and ii) greater than 2 cm (cT > 2 cm).We expected 5-year OS of ≥95% and parametrial involvement <2-3% for patients with cT ≤ 2 cm who underwent radical hysterectomy. Results. Of the 1269 patients enrolled, 604 were eligible for the planned analyses. Among these, 571 underwent radical hysterectomy (323 with cT ≤ 2 cm and 248 with cT > 2 cm). Parametrial involvement was present in 1.9% (6/323) with cT ≤ 2 cm and 12.9% (32/248) with cT > 2 cm. Five-year overall survivals were 95.8% (95% CI 92.9-97.6%) in cT ≤ 2 cm and 91.9% (95% CI 87.6-94.8%) in cT > 2 cm patients. Conclusion. Patients with cT ≤ 2 cm had lower risk of parametrial involvement and more favorable 5-year overall survival. They could therefore be good candidates for receiving less radical surgery.

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