Clinically applicable pharmacogenomics of anti-cancer drugs

Ichiro Ieiri, Shun Higuchi

Research output: Contribution to journalArticle

Abstract

In addition to drug metabolizing enzymes, drug transporters play an important role in pharmacodynamic (PD) and pharmacokinetic (PK) outcomes in anti-cancer drug therapy. Among the various drug transporters, ABC transporters such as MDR1, MRP1, MRP2 and BCRP are well known multiple anti-cancer drug resistance proteins. Individualized anti-cancer drug therapy based on the expression levels of these ABC transporters in cancer tissues has already been applied in the surgical treatment of glioblastoma and anaplastic astrocymota. OATP1B1 (organic anion transporting polypeptide 1B1), an influx transporter expressed at the basolateral membranes of hepatocytes, is also involved in the PK profile of irinotecan. Recent studies suggest that the screening of UGT1A1 variants (e.g., *28 and *60) and SLCO1B1 variants (especially for *15) is useful in irinotecan chemotherapy to avoid unpredicted severe toxicity.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalJapanese Journal of Clinical Pharmacology and Therapeutics
Volume39
Issue number6
DOIs
Publication statusPublished - Nov 1 2008

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irinotecan
Pharmacogenetics
ATP-Binding Cassette Transporters
Drug Therapy
Pharmaceutical Preparations
Neoplasms
Pharmacokinetics
Glioblastoma
Drug Resistance
Anions
Hepatocytes
Peptides
Membranes
Enzymes
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Clinically applicable pharmacogenomics of anti-cancer drugs. / Ieiri, Ichiro; Higuchi, Shun.

In: Japanese Journal of Clinical Pharmacology and Therapeutics, Vol. 39, No. 6, 01.11.2008, p. 233-237.

Research output: Contribution to journalArticle

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