Clinicopathologic characteristics of esophageal squamous cell carcinoma in younger patients

Tadahiro Nozoe, Hiroshi Saeki, Takefumi Ohga, Keizo Sugimachi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background. The aim of the current study was to find out the clinicopathologic characteristics of younger patients with squamous cell carcinoma of the esophagus. Methods. A total of 259 patients with esophageal squamous cell carcinoma who had been treated by esophagectomy and reconstruction within 10 years between January 1990 and December 1999 were studied. Clinicopathologic characteristics were compared between 27 patients younger than 50 years and 232 patients 50 years and older. Results. A significant difference was observed with regard to the size of the tumor (6.3 ± 3.8 cm in younger patients versus 5.0 ± 2.4 cm in older patients; p = 0.017). The proportion of patients with TNM stage III or IV in younger patients (59.3%, 16 of 27) was significantly higher than that in older patients (38.3%, 89 of 232; p = 0.020). Nevertheless, no significant difference in the 1-, 3-, and 5-year survival rates was observed between younger patients (77.2%, 54.7%, and 54.7%, respectively) and older patients (81.9%, 54.2%, and 48.8%, respectively). Conclusions. Although the prognosis of younger patients with esophageal squamous cell carcinoma did not differ from that of older patients, esophageal squamous cell carcinoma in younger patients has more malignant potential and aggressive activity.

Original languageEnglish
Pages (from-to)1914-1917
Number of pages4
JournalAnnals of Thoracic Surgery
Volume72
Issue number6
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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