Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine

Motohiro Esaki, Junji Umeno, Takanari Kitazono, Takayuki Matsumoto

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Chronic nonspecific multiple ulcers of the small intestine is a rare but distinct clinical condition, characterized by multiple small intestinal ulcers of nonspecific histology and chronic, persistent gastrointestinal bleeding without nonsteroidal anti-inflammatory drug use. However, because of the term “nonspecific” in its nomenclature, some gastroenterologists have misinterpreted the disease as the condition with small intestinal ulcers caused by undetermined etiologies without considering clinical features. Such misinterpretation has led to the heterogeneity of clinicopathologic features of the disease, as well as to ambiguity regarding a possible genetic contribution. It thus seems necessary to recognize the clinical entity of the disease precisely to avoid misinterpretation. In this review, we describe the clinicopathologic features, differential diagnosis, and the possibility of a genetic contribution to the disease.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalClinical Journal of Gastroenterology
Volume8
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

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Small Intestine
Ulcer
Terminology
Histology
Differential Diagnosis
Anti-Inflammatory Agents
Hemorrhage
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine. / Esaki, Motohiro; Umeno, Junji; Kitazono, Takanari; Matsumoto, Takayuki.

In: Clinical Journal of Gastroenterology, Vol. 8, No. 2, 01.04.2015, p. 57-62.

Research output: Contribution to journalReview article

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