Clinicopathologic significance of an immunohistochemical expression of p27 in scirrhous carcinoma of the breast.

Tadahiro Nozoe, Tsunehiro Oyama, Emiko Mori, Hidetaka Uramoto, Mitsuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto

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Abstract

BACKGROUND: Scirrhous carcinoma has been known to have more aggressive biological behavior than other histologic subtypes of invasive ductal carcinoma of the breast. The significance of expression of p27kip1, which is thought to be a tumor suppressor gene, in breast carcinoma remains controversial. The aim of the current study was to clarify clinicopathologic significance of scirrhous carcinoma of the breast with special reference to p27 expression. METHODS: Clinicopathologic features including immunohistochemical expression of p27 were compared between scirrhous carcinoma (n=42) and non-scirrhous invasive ductal carcinoma (papillotubular and solid-tubular carcinoma, n=63) of the breast. RESULTS: The proportion of pathologic lymph node metastasis among scirrhous carcinomas was significantly higher than that among carcinomas of other histologic types (papillotubular or solid-tubular carcinomas, p=0.029). The proportion of strong expression of p27 among scirrhous carcinomas was significantly lower than that among tumors of other histologic types (p<0.0001). CONCLUSIONS: Biological behavior of scirrhous carcinoma was found to be aggressive. The aggressiveness and poor cellular differentiation of scirrhous carcinoma of the breast might be related to low p27 expression.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalBreast cancer (Tokyo, Japan)
Volume14
Issue number3
DOIs
Publication statusPublished - Jan 1 2007

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

Cite this

Nozoe, T., Oyama, T., Mori, E., Uramoto, H., Takenoyama, M., Hanagiri, T., ... Yasumoto, K. (2007). Clinicopathologic significance of an immunohistochemical expression of p27 in scirrhous carcinoma of the breast. Breast cancer (Tokyo, Japan), 14(3), 277-280. https://doi.org/10.2325/jbcs.14.277