Abstract
Background: Hypoxia-inducible factor 1α (HIF-1α) plays a key role in responses to hypoxia and expression of HIF-1α downstream genes leads to both an adapted metabolism and increased oxygen supply. We investigated the clinical significance of HIF-1α expression in gastric carcinoma. Methods: We examined HIF-1α, vascular endothelial growth factor (VEGF), and insulin-like growth factor-2 (IGF-2) expression patterns immunohistochemically in 126 specimens of gastric carcinoma. CD34 antigen levels were also examined by immunohistochemistry to determine microvessel density (MVD) within tumors and correlations between HIF-1α expression, clinicopathological features, and survival were examined. Results: HIF-1α expression correlated with tumor size (P < 0.005), depth of invasion (P = 0.018), VEGF expression (P = 0.03), and intra-tumor MVD (P < 0.005). IGF-2 expression was more prevalent in HIF-1α positive than in HIF-1α negative tumors and the 5-year survival rate was 58.4% for HIF-1α positive patients and 81.5% for HIF-1α negative patients (P = 0.009). HIF-1α expression is an independent prognostic factor in gastric carcinoma (P = 0.032). Conclusions: Overexpression of HIF-1α in gastric carcinomas may upregulate its downstream gene products leading to VEGF-mediated angiogenesis, and resulting in a poor prognosis for patients.
| Original language | English |
|---|---|
| Pages (from-to) | 149-154 |
| Number of pages | 6 |
| Journal | Journal of Surgical Oncology |
| Volume | 94 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 1 2006 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
Cite this
Clinicopathologic significance of hypoxia-inducible factor 1α overexpression in gastric carcinomas. / Mizokami, Ken; Kakeji, Yoshihiro; Oda, Shinya; Irie, Koji; Yonemura, Tomohiro; Konishi, Fumio; Maehara, Yoshihiko.
In: Journal of Surgical Oncology, Vol. 94, No. 2, 01.08.2006, p. 149-154.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinicopathologic significance of hypoxia-inducible factor 1α overexpression in gastric carcinomas
AU - Mizokami, Ken
AU - Kakeji, Yoshihiro
AU - Oda, Shinya
AU - Irie, Koji
AU - Yonemura, Tomohiro
AU - Konishi, Fumio
AU - Maehara, Yoshihiko
PY - 2006/8/1
Y1 - 2006/8/1
N2 - Background: Hypoxia-inducible factor 1α (HIF-1α) plays a key role in responses to hypoxia and expression of HIF-1α downstream genes leads to both an adapted metabolism and increased oxygen supply. We investigated the clinical significance of HIF-1α expression in gastric carcinoma. Methods: We examined HIF-1α, vascular endothelial growth factor (VEGF), and insulin-like growth factor-2 (IGF-2) expression patterns immunohistochemically in 126 specimens of gastric carcinoma. CD34 antigen levels were also examined by immunohistochemistry to determine microvessel density (MVD) within tumors and correlations between HIF-1α expression, clinicopathological features, and survival were examined. Results: HIF-1α expression correlated with tumor size (P < 0.005), depth of invasion (P = 0.018), VEGF expression (P = 0.03), and intra-tumor MVD (P < 0.005). IGF-2 expression was more prevalent in HIF-1α positive than in HIF-1α negative tumors and the 5-year survival rate was 58.4% for HIF-1α positive patients and 81.5% for HIF-1α negative patients (P = 0.009). HIF-1α expression is an independent prognostic factor in gastric carcinoma (P = 0.032). Conclusions: Overexpression of HIF-1α in gastric carcinomas may upregulate its downstream gene products leading to VEGF-mediated angiogenesis, and resulting in a poor prognosis for patients.
AB - Background: Hypoxia-inducible factor 1α (HIF-1α) plays a key role in responses to hypoxia and expression of HIF-1α downstream genes leads to both an adapted metabolism and increased oxygen supply. We investigated the clinical significance of HIF-1α expression in gastric carcinoma. Methods: We examined HIF-1α, vascular endothelial growth factor (VEGF), and insulin-like growth factor-2 (IGF-2) expression patterns immunohistochemically in 126 specimens of gastric carcinoma. CD34 antigen levels were also examined by immunohistochemistry to determine microvessel density (MVD) within tumors and correlations between HIF-1α expression, clinicopathological features, and survival were examined. Results: HIF-1α expression correlated with tumor size (P < 0.005), depth of invasion (P = 0.018), VEGF expression (P = 0.03), and intra-tumor MVD (P < 0.005). IGF-2 expression was more prevalent in HIF-1α positive than in HIF-1α negative tumors and the 5-year survival rate was 58.4% for HIF-1α positive patients and 81.5% for HIF-1α negative patients (P = 0.009). HIF-1α expression is an independent prognostic factor in gastric carcinoma (P = 0.032). Conclusions: Overexpression of HIF-1α in gastric carcinomas may upregulate its downstream gene products leading to VEGF-mediated angiogenesis, and resulting in a poor prognosis for patients.
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U2 - 10.1002/jso.20568
DO - 10.1002/jso.20568
M3 - Article
C2 - 16847924
AN - SCOPUS:33747097563
VL - 94
SP - 149
EP - 154
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 2
ER -