Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma

T. Koga, S. Hashimoto, K. Sugio, I. Yoshino, S. Mojtahedzadeh, Y. Matsuo, Yoshikazu Yonemitsu, K. Sugimachi, K. Sueishi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Although human lung adenocarcinoma has diverse histological subtypes, the correlation between histological subtypes and occurrence of the p53 gene mutation has been given less attention. We investigated 145 surgically resected lung adenocarcinomas to search for the incidence of p53 mutations and for record data on survival in each histological subtype, according to the new WHO criteria (1999). The frequency of p53 mutation in bronchioloalveolar carcinoma (BAC; 0% in 17 cases) and BAC with invasive growth component (BAC-invasive; 11% in 27 cases), which is conventionally categorized as the mixed subtype in WHO typing, were apparently significantly lower than in other types (non-BAC including acinar, papillary, solid, or mixed histology with these subtypes; 48% in 101 cases; P < 0.01). Multivariate analysis revealed that the histological subtype including BAC-invasive was a strong, independent, and significant prognostic factor (P < 0.03), as were tumor size and pathological stage (P < 0.001 and 0.002, respectively) for overall survival. However, the occurrence of p53 mutation itself was seen to be significant only in case of the univariate analysis. Therefore, histological subtyping may be a better prognostic indicator than is p53 mutation. These findings suggest that the WHO classification with the BAC and BAC-invasive from other histological subtypes may prove useful to predict the outcome for surgically treated patients with lung adenocarcinoma.

Original languageEnglish
Pages (from-to)1730-1738
Number of pages9
JournalClinical Cancer Research
Volume7
Issue number6
Publication statusPublished - Aug 15 2001

Fingerprint

Mutation
Bronchiolo-Alveolar Adenocarcinoma
Survival
p53 Genes
Mutation Rate
Histology
Multivariate Analysis
Adenocarcinoma of lung
Incidence
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Koga, T., Hashimoto, S., Sugio, K., Yoshino, I., Mojtahedzadeh, S., Matsuo, Y., ... Sueishi, K. (2001). Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma. Clinical Cancer Research, 7(6), 1730-1738.

Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma. / Koga, T.; Hashimoto, S.; Sugio, K.; Yoshino, I.; Mojtahedzadeh, S.; Matsuo, Y.; Yonemitsu, Yoshikazu; Sugimachi, K.; Sueishi, K.

In: Clinical Cancer Research, Vol. 7, No. 6, 15.08.2001, p. 1730-1738.

Research output: Contribution to journalArticle

Koga, T, Hashimoto, S, Sugio, K, Yoshino, I, Mojtahedzadeh, S, Matsuo, Y, Yonemitsu, Y, Sugimachi, K & Sueishi, K 2001, 'Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma', Clinical Cancer Research, vol. 7, no. 6, pp. 1730-1738.
Koga, T. ; Hashimoto, S. ; Sugio, K. ; Yoshino, I. ; Mojtahedzadeh, S. ; Matsuo, Y. ; Yonemitsu, Yoshikazu ; Sugimachi, K. ; Sueishi, K. / Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma. In: Clinical Cancer Research. 2001 ; Vol. 7, No. 6. pp. 1730-1738.
@article{044e9e4231c34f15a1db1b8d52940c2d,
title = "Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma",
abstract = "Although human lung adenocarcinoma has diverse histological subtypes, the correlation between histological subtypes and occurrence of the p53 gene mutation has been given less attention. We investigated 145 surgically resected lung adenocarcinomas to search for the incidence of p53 mutations and for record data on survival in each histological subtype, according to the new WHO criteria (1999). The frequency of p53 mutation in bronchioloalveolar carcinoma (BAC; 0{\%} in 17 cases) and BAC with invasive growth component (BAC-invasive; 11{\%} in 27 cases), which is conventionally categorized as the mixed subtype in WHO typing, were apparently significantly lower than in other types (non-BAC including acinar, papillary, solid, or mixed histology with these subtypes; 48{\%} in 101 cases; P < 0.01). Multivariate analysis revealed that the histological subtype including BAC-invasive was a strong, independent, and significant prognostic factor (P < 0.03), as were tumor size and pathological stage (P < 0.001 and 0.002, respectively) for overall survival. However, the occurrence of p53 mutation itself was seen to be significant only in case of the univariate analysis. Therefore, histological subtyping may be a better prognostic indicator than is p53 mutation. These findings suggest that the WHO classification with the BAC and BAC-invasive from other histological subtypes may prove useful to predict the outcome for surgically treated patients with lung adenocarcinoma.",
author = "T. Koga and S. Hashimoto and K. Sugio and I. Yoshino and S. Mojtahedzadeh and Y. Matsuo and Yoshikazu Yonemitsu and K. Sugimachi and K. Sueishi",
year = "2001",
month = "8",
day = "15",
language = "English",
volume = "7",
pages = "1730--1738",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "6",

}

TY - JOUR

T1 - Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma

AU - Koga, T.

AU - Hashimoto, S.

AU - Sugio, K.

AU - Yoshino, I.

AU - Mojtahedzadeh, S.

AU - Matsuo, Y.

AU - Yonemitsu, Yoshikazu

AU - Sugimachi, K.

AU - Sueishi, K.

PY - 2001/8/15

Y1 - 2001/8/15

N2 - Although human lung adenocarcinoma has diverse histological subtypes, the correlation between histological subtypes and occurrence of the p53 gene mutation has been given less attention. We investigated 145 surgically resected lung adenocarcinomas to search for the incidence of p53 mutations and for record data on survival in each histological subtype, according to the new WHO criteria (1999). The frequency of p53 mutation in bronchioloalveolar carcinoma (BAC; 0% in 17 cases) and BAC with invasive growth component (BAC-invasive; 11% in 27 cases), which is conventionally categorized as the mixed subtype in WHO typing, were apparently significantly lower than in other types (non-BAC including acinar, papillary, solid, or mixed histology with these subtypes; 48% in 101 cases; P < 0.01). Multivariate analysis revealed that the histological subtype including BAC-invasive was a strong, independent, and significant prognostic factor (P < 0.03), as were tumor size and pathological stage (P < 0.001 and 0.002, respectively) for overall survival. However, the occurrence of p53 mutation itself was seen to be significant only in case of the univariate analysis. Therefore, histological subtyping may be a better prognostic indicator than is p53 mutation. These findings suggest that the WHO classification with the BAC and BAC-invasive from other histological subtypes may prove useful to predict the outcome for surgically treated patients with lung adenocarcinoma.

AB - Although human lung adenocarcinoma has diverse histological subtypes, the correlation between histological subtypes and occurrence of the p53 gene mutation has been given less attention. We investigated 145 surgically resected lung adenocarcinomas to search for the incidence of p53 mutations and for record data on survival in each histological subtype, according to the new WHO criteria (1999). The frequency of p53 mutation in bronchioloalveolar carcinoma (BAC; 0% in 17 cases) and BAC with invasive growth component (BAC-invasive; 11% in 27 cases), which is conventionally categorized as the mixed subtype in WHO typing, were apparently significantly lower than in other types (non-BAC including acinar, papillary, solid, or mixed histology with these subtypes; 48% in 101 cases; P < 0.01). Multivariate analysis revealed that the histological subtype including BAC-invasive was a strong, independent, and significant prognostic factor (P < 0.03), as were tumor size and pathological stage (P < 0.001 and 0.002, respectively) for overall survival. However, the occurrence of p53 mutation itself was seen to be significant only in case of the univariate analysis. Therefore, histological subtyping may be a better prognostic indicator than is p53 mutation. These findings suggest that the WHO classification with the BAC and BAC-invasive from other histological subtypes may prove useful to predict the outcome for surgically treated patients with lung adenocarcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0034906305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034906305&partnerID=8YFLogxK

M3 - Article

C2 - 11410513

AN - SCOPUS:0034906305

VL - 7

SP - 1730

EP - 1738

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 6

ER -