Abstract
Background and Objectives: Clinicopathological significance of colorectal mucinous carcinoma (MC) remains controversial. The aim of the current study was to investigate the clinicopathological characteristics of colorectal MC. Methods: Eighteen patients with MC and 265 with moderately or well differentiated adenocarcinoma of the colon and rectum, were clinicopathologically compared. Results: MCs occurred in the fight colon significantly more frequently than did non-mucinous carcinomas (NMCs). The maximal size of the tumors in MCs (7.0 ± 2.9 cm) was significantly larger than that in NMCs (5.1 ± 2.1 cm) (P < 0.001). Although the ratio of patients with peritoneal metastasis in MCs (22.2%; 4/18) was significantly higher than that in NMCs (6.0%; 16/265) (P < 0.05), there was no significant difference regarding liver metastasis. The proportion of lymph node metastasis in MCs (72.2%; 13/18) was significantly higher than that in NMCs (44.9%; 119/265) (P < 0.05). There was no significant difference regarding the lymphatic and venous invasion. The 1-, 3-, and 5-year survival rates of patients with MCs were 77.8%, 45.4%, and 30.3%, respectively, and were significantly lower than those in patients with NMCs, that were 88.9%, 65.6%, and 60.8%, respectively (P < 0.05). Conclusions: As colorectal MCs proliferate and metastasize more rapidly than do NMCs, surgeons should realize that more aggressive surgical treatment should be occasionally administered to improve the postoperative prognosis of the patients with colorectal MCs. (C) 2000 Wiley-Liss, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 103-107 |
| Number of pages | 5 |
| Journal | Journal of Surgical Oncology |
| Volume | 75 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 18 2000 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
Cite this
Clinicopathological characteristics of mucinous carcinoma of the colon and rectum. / Nozoe, Tadahiro; Anai, Hideaki; Nasu, Shinji; Sugimachi, Keizo.
In: Journal of Surgical Oncology, Vol. 75, No. 2, 18.11.2000, p. 103-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinicopathological characteristics of mucinous carcinoma of the colon and rectum
AU - Nozoe, Tadahiro
AU - Anai, Hideaki
AU - Nasu, Shinji
AU - Sugimachi, Keizo
PY - 2000/11/18
Y1 - 2000/11/18
N2 - Background and Objectives: Clinicopathological significance of colorectal mucinous carcinoma (MC) remains controversial. The aim of the current study was to investigate the clinicopathological characteristics of colorectal MC. Methods: Eighteen patients with MC and 265 with moderately or well differentiated adenocarcinoma of the colon and rectum, were clinicopathologically compared. Results: MCs occurred in the fight colon significantly more frequently than did non-mucinous carcinomas (NMCs). The maximal size of the tumors in MCs (7.0 ± 2.9 cm) was significantly larger than that in NMCs (5.1 ± 2.1 cm) (P < 0.001). Although the ratio of patients with peritoneal metastasis in MCs (22.2%; 4/18) was significantly higher than that in NMCs (6.0%; 16/265) (P < 0.05), there was no significant difference regarding liver metastasis. The proportion of lymph node metastasis in MCs (72.2%; 13/18) was significantly higher than that in NMCs (44.9%; 119/265) (P < 0.05). There was no significant difference regarding the lymphatic and venous invasion. The 1-, 3-, and 5-year survival rates of patients with MCs were 77.8%, 45.4%, and 30.3%, respectively, and were significantly lower than those in patients with NMCs, that were 88.9%, 65.6%, and 60.8%, respectively (P < 0.05). Conclusions: As colorectal MCs proliferate and metastasize more rapidly than do NMCs, surgeons should realize that more aggressive surgical treatment should be occasionally administered to improve the postoperative prognosis of the patients with colorectal MCs. (C) 2000 Wiley-Liss, Inc.
AB - Background and Objectives: Clinicopathological significance of colorectal mucinous carcinoma (MC) remains controversial. The aim of the current study was to investigate the clinicopathological characteristics of colorectal MC. Methods: Eighteen patients with MC and 265 with moderately or well differentiated adenocarcinoma of the colon and rectum, were clinicopathologically compared. Results: MCs occurred in the fight colon significantly more frequently than did non-mucinous carcinomas (NMCs). The maximal size of the tumors in MCs (7.0 ± 2.9 cm) was significantly larger than that in NMCs (5.1 ± 2.1 cm) (P < 0.001). Although the ratio of patients with peritoneal metastasis in MCs (22.2%; 4/18) was significantly higher than that in NMCs (6.0%; 16/265) (P < 0.05), there was no significant difference regarding liver metastasis. The proportion of lymph node metastasis in MCs (72.2%; 13/18) was significantly higher than that in NMCs (44.9%; 119/265) (P < 0.05). There was no significant difference regarding the lymphatic and venous invasion. The 1-, 3-, and 5-year survival rates of patients with MCs were 77.8%, 45.4%, and 30.3%, respectively, and were significantly lower than those in patients with NMCs, that were 88.9%, 65.6%, and 60.8%, respectively (P < 0.05). Conclusions: As colorectal MCs proliferate and metastasize more rapidly than do NMCs, surgeons should realize that more aggressive surgical treatment should be occasionally administered to improve the postoperative prognosis of the patients with colorectal MCs. (C) 2000 Wiley-Liss, Inc.
UR - http://www.scopus.com/inward/record.url?scp=0033759640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033759640&partnerID=8YFLogxK
U2 - 10.1002/1096-9098(200010)75:2<103::AID-JSO6>3.0.CO;2-C
DO - 10.1002/1096-9098(200010)75:2<103::AID-JSO6>3.0.CO;2-C
M3 - Article
C2 - 11064389
AN - SCOPUS:0033759640
VL - 75
SP - 103
EP - 107
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 2
ER -