Clinicopathological characteristics of mucinous carcinoma of the colon and rectum

Tadahiro Nozoe, Hideaki Anai, Shinji Nasu, Keizo Sugimachi

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Background and Objectives: Clinicopathological significance of colorectal mucinous carcinoma (MC) remains controversial. The aim of the current study was to investigate the clinicopathological characteristics of colorectal MC. Methods: Eighteen patients with MC and 265 with moderately or well differentiated adenocarcinoma of the colon and rectum, were clinicopathologically compared. Results: MCs occurred in the fight colon significantly more frequently than did non-mucinous carcinomas (NMCs). The maximal size of the tumors in MCs (7.0 ± 2.9 cm) was significantly larger than that in NMCs (5.1 ± 2.1 cm) (P < 0.001). Although the ratio of patients with peritoneal metastasis in MCs (22.2%; 4/18) was significantly higher than that in NMCs (6.0%; 16/265) (P < 0.05), there was no significant difference regarding liver metastasis. The proportion of lymph node metastasis in MCs (72.2%; 13/18) was significantly higher than that in NMCs (44.9%; 119/265) (P < 0.05). There was no significant difference regarding the lymphatic and venous invasion. The 1-, 3-, and 5-year survival rates of patients with MCs were 77.8%, 45.4%, and 30.3%, respectively, and were significantly lower than those in patients with NMCs, that were 88.9%, 65.6%, and 60.8%, respectively (P < 0.05). Conclusions: As colorectal MCs proliferate and metastasize more rapidly than do NMCs, surgeons should realize that more aggressive surgical treatment should be occasionally administered to improve the postoperative prognosis of the patients with colorectal MCs. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalJournal of Surgical Oncology
Volume75
Issue number2
DOIs
Publication statusPublished - Nov 18 2000

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Mucinous Adenocarcinoma
Rectum
Colon
Carcinoma
Neoplasm Metastasis
Colorectal Neoplasms
Adenocarcinoma
Survival Rate
Lymph Nodes
Liver
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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Clinicopathological characteristics of mucinous carcinoma of the colon and rectum. / Nozoe, Tadahiro; Anai, Hideaki; Nasu, Shinji; Sugimachi, Keizo.

In: Journal of Surgical Oncology, Vol. 75, No. 2, 18.11.2000, p. 103-107.

Research output: Contribution to journalArticle

Nozoe, Tadahiro ; Anai, Hideaki ; Nasu, Shinji ; Sugimachi, Keizo. / Clinicopathological characteristics of mucinous carcinoma of the colon and rectum. In: Journal of Surgical Oncology. 2000 ; Vol. 75, No. 2. pp. 103-107.
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abstract = "Background and Objectives: Clinicopathological significance of colorectal mucinous carcinoma (MC) remains controversial. The aim of the current study was to investigate the clinicopathological characteristics of colorectal MC. Methods: Eighteen patients with MC and 265 with moderately or well differentiated adenocarcinoma of the colon and rectum, were clinicopathologically compared. Results: MCs occurred in the fight colon significantly more frequently than did non-mucinous carcinomas (NMCs). The maximal size of the tumors in MCs (7.0 ± 2.9 cm) was significantly larger than that in NMCs (5.1 ± 2.1 cm) (P < 0.001). Although the ratio of patients with peritoneal metastasis in MCs (22.2{\%}; 4/18) was significantly higher than that in NMCs (6.0{\%}; 16/265) (P < 0.05), there was no significant difference regarding liver metastasis. The proportion of lymph node metastasis in MCs (72.2{\%}; 13/18) was significantly higher than that in NMCs (44.9{\%}; 119/265) (P < 0.05). There was no significant difference regarding the lymphatic and venous invasion. The 1-, 3-, and 5-year survival rates of patients with MCs were 77.8{\%}, 45.4{\%}, and 30.3{\%}, respectively, and were significantly lower than those in patients with NMCs, that were 88.9{\%}, 65.6{\%}, and 60.8{\%}, respectively (P < 0.05). Conclusions: As colorectal MCs proliferate and metastasize more rapidly than do NMCs, surgeons should realize that more aggressive surgical treatment should be occasionally administered to improve the postoperative prognosis of the patients with colorectal MCs. (C) 2000 Wiley-Liss, Inc.",
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